Zykova T Yu, Popova O O, Khoroshko V A, Levitsky V G, Lavrov S A, Zhimulev I F
Institute of Molecular and Cell Biology, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia.
Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia.
Dokl Biochem Biophys. 2018 Nov;483(1):297-301. doi: 10.1134/S1607672918060078.
New data on the organization of genes entirely located in the open domains for chromatin transcription and occupying only one chromosome structure (interband) were obtained. The characteristic features of these genes are the small size (on average, 1-2 kb), depletion of the replicative complex proteins in the regulatory region, and the presence of specific motifs for binding transcription factors, as compared to the genes occupying two structures (interband and gray band). The biological function of these genes is associated primarily with the processes of gene expression and RNA metabolism.
获得了关于完全位于染色质转录开放域且仅占据一种染色体结构（间带）的基因组织的新数据。与占据两种结构（间带和灰带）的基因相比，这些基因的特征是尺寸小（平均1 - 2 kb）、调控区域中复制复合体蛋白缺失以及存在结合转录因子的特定基序。这些基因的生物学功能主要与基因表达和RNA代谢过程相关。
