Gao Yan, Chu Shi-Feng, Zhang Zhao, Ai Qi-Di, Xia Cong-Yuan, Huang Hui-Yong, Chen Nai-Hong
a Department of Pharmacology, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
b College of Pharmacy , Hunan University of Chinese Medicine, Changsha 410208, China.
J Asian Nat Prod Res. 2019 Aug;21(8):782-797. doi: 10.1080/10286020.2018.1504024. Epub 2019 Jan 4.
Inappropriate use of acetaminophen (APAP) can lead to morbidity and mortality secondary to hepatic necrosis. Ginsenoside Rg1 is a major active ingredient in processed , which is proved to elicit biological effects. We hypothesized the beneficial effect of Rg1 on APAP-mediated hepatotoxicity was through Nrf2/ARE pathway. The study was conducted in cells and mice, comparing the actions of Rg1. Rg1 significantly improved cell survival rates and promoted the expression of antioxidant proteins. Meanwhile, Rg1 reduced the excessive ROS and the occurrence of cell apoptosis, which were related to Nrf2/ARE pathway. Expression of Nrf2 has a certain cell specificity.
对乙酰氨基酚（APAP）使用不当可导致继发于肝坏死的发病和死亡。人参皂苷Rg1是炮制后的主要活性成分，已被证明具有生物学效应。我们推测Rg1对APAP介导的肝毒性的有益作用是通过Nrf2/ARE途径实现的。该研究在细胞和小鼠中进行，比较了Rg1的作用。Rg1显著提高了细胞存活率并促进了抗氧化蛋白的表达。同时，Rg1减少了过量的活性氧（ROS）和细胞凋亡的发生，这与Nrf2/ARE途径有关。Nrf2的表达具有一定的细胞特异性。
