National Resource Center for Chinese Materia Medica, State Key Laboratory Breeding Base of Dao-di Herbs, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Guang'anmen Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing 100053, China.
Oxid Med Cell Longev. 2020 Sep 27;2020:5430407. doi: 10.1155/2020/5430407. eCollection 2020.
Oxidative stress (OS) refers to the physiological imbalance between oxidative and antioxidative processes leading to increased oxidation, which then results in the inflammatory infiltration of neutrophils, increased protease secretion, and the production of a large number of oxidative intermediates. Oxidative stress is considered an important factor in the pathogenesis of cardiovascular disease (CVD). At present, active components of Chinese herbal medicines (CHMs) have been widely used for the treatment of CVD, including coronary heart disease and hypertension. Since the discovery of artemisinin for the treatment of malaria by Nobel laureate Youyou Tu, the therapeutic effects of active components of CHM on various diseases have been widely investigated by the medical community. It has been found that various active CHM components can regulate oxidative stress and the circulatory system, including ginsenoside, astragaloside, and resveratrol. This paper reviews advances in the use of active CHM components that modulate oxidative stress, suggesting potential drugs for the treatment of various CVDs.
氧化应激（OS）是指氧化和抗氧化过程之间的生理失衡，导致氧化增加，进而导致中性粒细胞的炎症浸润、蛋白酶分泌增加以及大量氧化中间产物的产生。氧化应激被认为是心血管疾病（CVD）发病机制中的一个重要因素。目前，中草药（CHM）的活性成分已被广泛用于治疗 CVD，包括冠心病和高血压。自诺贝尔生理学或医学奖得主屠呦呦发现青蒿素治疗疟疾以来，医学界广泛研究了 CHM 活性成分对各种疾病的治疗效果。已经发现，各种活性 CHM 成分可以调节氧化应激和循环系统，包括人参皂苷、黄芪甲苷和白藜芦醇。本文综述了调节氧化应激的 CHM 活性成分的应用进展，为治疗各种 CVD 的潜在药物提供了依据。
