Cohen Diana K, Goldberg David J
Skin Laser & Surgical Specialists of NY and NJ, Hackensack, New Jersey.
Icahn School of Medicine at Mt. Sinai, New York, New York.
Dermatol Surg. 2019 Mar;45(3):329-339. doi: 10.1097/DSS.0000000000001701.
Mohs micrographic surgery (MMS) is a frequently used technique that provides total margin visualization for treatment of skin neoplasms.
To provide a comprehensive review of MMS literature, focusing on its origins, evidence behind present-day uses of MMS, and future directions.
A literature search was conducted using PubMed to identify articles pertaining to MMS.
The fresh frozen technique led to widespread use of MMS in the 1970s. One randomized controlled trial and several large prospective studies have demonstrated low recurrence rates for treatment of nonmelanoma skin cancer (NMSC). MMS, when compared with surgical excision, also achieved a statistically significant higher cure rate for treatment of recurrent NMSC. Studies have demonstrated low recurrence for the treatment of melanoma and melanoma in situ with MMS. MMS has also been shown to effectively treat several rare cutaneous neoplasms. The future of MMS is likely to include the adoption of noninvasive imaging, immunostaining, and digital technology.
Mohs micrographic surgery is an effective treatment modality for numerous cutaneous neoplasms. It has achieved statistically significant superiority to surgical excision for the treatment of recurrent and high-risk NMSC. The future is likely to see increased use of noninvasive imaging, immunostaining, and digital technology.
莫氏显微外科手术（MMS）是一种常用技术，可在治疗皮肤肿瘤时实现对切缘的全面可视化。
对莫氏显微外科手术的文献进行全面综述，重点关注其起源、当前使用莫氏显微外科手术的依据以及未来发展方向。
使用PubMed进行文献检索，以识别与莫氏显微外科手术相关的文章。
新鲜冷冻技术促使莫氏显微外科手术在20世纪70年代得到广泛应用。一项随机对照试验和几项大型前瞻性研究表明，非黑色素瘤皮肤癌（NMSC）的治疗复发率较低。与手术切除相比，莫氏显微外科手术在治疗复发性NMSC时也取得了统计学上显著更高的治愈率。研究表明，用莫氏显微外科手术治疗黑色素瘤和原位黑色素瘤的复发率较低。莫氏显微外科手术还被证明能有效治疗几种罕见的皮肤肿瘤。莫氏显微外科手术的未来可能包括采用非侵入性成像、免疫染色和数字技术。
莫氏显微外科手术是治疗多种皮肤肿瘤的有效治疗方式。在治疗复发性和高危NMSC方面，它已在统计学上显著优于手术切除。未来可能会更多地使用非侵入性成像、免疫染色和数字技术。
