Eye Center, Renmin Hospital of Wuhan University, Wuhan, China.
Retina. 2020 Apr;40(4):743-749. doi: 10.1097/IAE.0000000000002441.
To characterize features of central serous chorioretinopathy (CSC) using multicolor (MC) imaging and to compare the efficacy of using MC imaging and traditional color fundus photography (CFP) for detecting features of CSC.
A retrospective review of 75 eyes of 69 participants with CSC from the Eye Center of the Renmin Hospital of Wuhan University. The patients underwent same-day CFP, fundus fluorescein angiography (FFA), spectral domain optical coherence tomography (SD-OCT), and MC imaging (including infrared reflectance (IR), green reflectance (GR), blue reflectance (BR), combined standard MC image, and green-blue-enhanced image). Positive CSC lesions were evaluated using FFA and SD-OCT. Features in images of CFP, standard MC, green-blue-enhanced, IR, GR, and BR were analyzed and calculated.
Among the 75 eyes of 69 patients, 75 eyes with subretinal fluid (SRF) and retinal pigment epithelial (RPE) leakage point, and 43 eyes with RPE damage were observed by FFA and SD-OCT. The detection rate of SRF was significantly higher with the standard MC image (92.0%), green-blue-enhanced image (92.0%), IR (88.0%), and GR (88.0%) than that with CFP (66.7%) (P < 0.05). Blue reflectance (45.3%) was associated with lower rate of SRF detection compared to CFP (P < 0.05). The standard MC image (84.0%), green-blue-enhanced image (84.0%), IR (78.7%), and GR (80%) delineated the boundaries of SRF more effectively than CFP (44%). The abnormal areas corresponding to RPE leakage points on FFA were observed with the standard MC image, green-blue-enhanced image, and IR at detection rates of 90.7, 82.7, and 90.7%, respectively, which were significantly higher than with CFP (29.3%) (P < 0.05). However, the detection rates of the abnormalities corresponding to leakage on FFA were lower with GR (5.3%) and BR (1.3%) than those with CFP (P < 0.05). Areas of RPE damage on FFA were observed at the same locations with the standard MC image, green-blue-enhanced image, and IR at detection rates of 97.7, 93.0, and 95.3%, respectively, which were significantly higher than with CFP (41.9%) (P < 0.05). Compared with CFP, the detectable rates of RPE damage on GR (14.0%) and BR (9.3%) were lower (P < 0.05).
As an adjunct to SD-OCT, the MC image can delineate the extent or boundaries of SRF more effectively than CFP. As an adjunct to FFA, the MC image can identify foci of leakage more effectively than CFP. The MC image, particularly the IR channel, can identify areas of RPE damage more effectively than CFP. Therefore, the MC image may be a useful adjunct to FFA and OCT for detecting or monitoring CSC.
使用多光谱（MC）成像来描述中心性浆液性脉络膜视网膜病变（CSC）的特征，并比较使用 MC 成像和传统眼底彩色摄影（CFP）检测 CSC 特征的效果。
对来自武汉大学人民医院眼科中心的 69 名患者的 75 只眼的 CSC 进行回顾性研究。患者在同一天接受 CFP、眼底荧光素血管造影（FFA）、谱域光学相干断层扫描（SD-OCT）和 MC 成像（包括红外反射（IR）、绿反射（GR）、蓝反射（BR）、标准 MC 图像组合和绿-蓝增强图像）。使用 FFA 和 SD-OCT 评估阳性 CSC 病变。分析和计算 CFP、标准 MC、绿-蓝增强、IR、GR 和 BR 图像中的特征。
在 69 名患者的 75 只眼中，75 只眼有视网膜下液（SRF）和视网膜色素上皮（RPE）渗漏点，43 只眼有 RPE 损伤，通过 FFA 和 SD-OCT 观察到。与 CFP（66.7%）相比，标准 MC 图像（92.0%）、绿-蓝增强图像（92.0%）、IR（88.0%）和 GR（88.0%）检测到 SRF 的比例显著更高（P < 0.05）。与 CFP 相比，BR（45.3%）检测到 SRF 的比例较低（P < 0.05）。标准 MC 图像（84.0%）、绿-蓝增强图像（84.0%）、IR（78.7%）和 GR（80%）比 CFP（44%）更有效地描绘了 SRF 的边界（P < 0.05）。FFA 上对应 RPE 渗漏点的异常区域分别用标准 MC 图像、绿-蓝增强图像和 IR 以 90.7%、82.7%和 90.7%的检出率观察到，明显高于 CFP（29.3%）（P < 0.05）。然而，GR（5.3%）和 BR（1.3%）对应 FFA 上渗漏的异常区域的检出率低于 CFP（P < 0.05）。FFA 上 RPE 损伤的区域在标准 MC 图像、绿-蓝增强图像和 IR 中以 97.7%、93.0%和 95.3%的检出率观察到相同的位置，明显高于 CFP（41.9%）（P < 0.05）。与 CFP 相比，GR（14.0%）和 BR（9.3%）检测到 RPE 损伤的比例较低（P < 0.05）。
作为 SD-OCT 的辅助手段，MC 图像比 CFP 更有效地描绘 SRF 的范围或边界。作为 FFA 的辅助手段，MC 图像比 CFP 更有效地识别渗漏点。MC 图像，特别是 IR 通道，比 CFP 更有效地识别 RPE 损伤区域。因此，MC 图像可能是 FFA 和 OCT 检测或监测 CSC 的有用辅助手段。
