Takenaka Shota, Makino Takahiro, Sakai Yusuke, Kashii Masafumi, Iwasaki Motoki, Yoshikawa Hideki, Kaito Takashi
Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka.
Orthopaedic Surgery, Toyonaka Municipal Hospital, Toyonaka, Osaka.
Medicine (Baltimore). 2019 Jan;98(1):e13970. doi: 10.1097/MD.0000000000013970.
Prospective case-control study.This study used a prospective multicenter database to investigate whether dural tear (DT) is associated with an increased rate of other perioperative complications.Few studies have had sufficient data accuracy and statistical power to evaluate the association between DT and other complications owing to a low incidence of occurrence.Between 2012 and 2017, 13,188 patients (7174 men and 6014 women) with degenerative lumbar diseases underwent primary lumbar spine surgery. The average age was 64.8 years for men and 68.7 years for women. DT was defined as a tear that was detected intraoperatively. Other investigated intraoperative surgery-related complications were massive hemorrhage (>2 L of blood loss), nerve injury, screw malposition, cage/graft dislocation, surgery performed at the wrong site, and vascular injury. The examined postoperative surgery-related complications were dural leak, surgical-site infection (SSI), postoperative neurological deficit, postoperative hematoma, wound dehiscence, screw/rod failure, and cage/graft failure. Information related to perioperative systemic complications was also collected for cardiovascular diseases, respiratory diseases, renal and urological diseases, cerebrovascular diseases, postoperative delirium, and sepsis.DTs occurred in 451/13,188 patients (3.4%, the DT group). In the DT group, dural leak was observed in 88 patients. After controlling for the potentially confounding variables of age, sex, primary disease, and type of procedure, the surgery-related complications that were more likely to occur in the DT group than in the non-DT group were SSI (odds ratio [OR] 2.68) and postoperative neurological deficit (OR 3.27). As for perioperative systemic complications, the incidence of postoperative delirium (OR 3.21) was significantly high in the DT group.This study demonstrated that DT was associated with higher incidences of postoperative SSI, postoperative neurological deficit, and postoperative delirium, in addition to directly DT-related dural leak.
前瞻性病例对照研究。本研究使用前瞻性多中心数据库来调查硬脑膜撕裂(DT)是否与其他围手术期并发症的发生率增加相关。由于DT的发生率较低,很少有研究具备足够的数据准确性和统计效力来评估DT与其他并发症之间的关联。在2012年至2017年间,13188例患有退行性腰椎疾病的患者(7174例男性和6014例女性)接受了初次腰椎手术。男性的平均年龄为64.8岁,女性为68.7岁。DT被定义为术中检测到的撕裂。其他调查的术中手术相关并发症包括大量出血(失血>2升)、神经损伤、螺钉位置不当、椎间融合器/移植物脱位、手术部位错误以及血管损伤。检查的术后手术相关并发症包括硬膜漏、手术部位感染(SSI)、术后神经功能缺损、术后血肿、伤口裂开、螺钉/棒失败以及椎间融合器/移植物失败。还收集了与围手术期全身性并发症相关的信息,包括心血管疾病、呼吸系统疾病、肾脏和泌尿系统疾病、脑血管疾病、术后谵妄以及脓毒症。451/13188例患者(3.4%,DT组)发生了DT。在DT组中,88例患者观察到硬膜漏。在控制了年龄、性别、原发疾病和手术类型等潜在混杂变量后,DT组比非DT组更易发生的手术相关并发症为SSI(比值比[OR]2.68)和术后神经功能缺损(OR 3.27)。至于围手术期全身性并发症,DT组术后谵妄的发生率(OR 3.21)显著较高。本研究表明,除了与DT直接相关的硬膜漏外,DT还与术后SSI、术后神经功能缺损和术后谵妄的较高发生率相关。