Department of Neurological Surgery, University of Washington, Seattle, WA, USA.
Department of Biostatistics, University of Washington, Seattle, WA, USA.
Arch Clin Neuropsychol. 2019 Oct 24;34(7):1165-1174. doi: 10.1093/arclin/acy103.
The Functional Status Examination (FSE) is a comprehensive measure of functional status post-traumatic brain injury (TBI) that has primarily been used in studies of moderate-to-severe TBI. The present observational study examines functional status using the FSE among patients who sustained mild TBIs (mTBIs; defined as Glasgow Coma Scale [GCS] = 13-15 at admission) seen in a Level 1 trauma center. Study aims included examining the course of functional status following mTBI, as well as exploring relationships of the FSE and other relevant constructs among those with GCS = 13-15.
Participants were assessed at 2 weeks (n = 112), 3 months (n = 113), 6 months (n = 106), and 12 months (n = 88) post-injury for changes in functional status resulting both (a) from all injuries and (b) from TBI only.
Among seven domains of day-to-day functioning, participants generally experienced the greatest disruption in their primary activity (work or school) and in leisure and recreation. Subjects' overall functional status tended to improve over time, with sharpest increases in functionality occurring in the first 3 months post-injury. However, some subjects continued to report functional limitations even at 12 months post-injury. Functional status was largely unrelated to neurocognitive functioning, but related strongly to post-traumatic symptoms, life satisfaction, and emotional well-being, particularly at 3 months post-injury and beyond.
Findings indicate that functional impairments related to mTBI may be more likely to persist than widely believed, with those who experience lingering functional deficits at particular risk for emotional health difficulties.
功能状态检查(FSE)是一种全面的创伤性脑损伤(TBI)后功能状态测量方法,主要用于中重度 TBI 的研究。本观察性研究在 1 级创伤中心就诊的轻度 TBI(mTBI;定义为入院时格拉斯哥昏迷量表 [GCS] = 13-15)患者中使用 FSE 检查功能状态。研究目的包括检查 mTBI 后功能状态的变化,并探讨 FSE 与其他相关结构之间的关系在 GCS = 13-15 的患者中。
参与者在受伤后 2 周(n = 112)、3 个月(n = 113)、6 个月(n = 106)和 12 个月(n = 88)进行评估,以了解所有损伤和 TBI 仅造成的功能状态变化。
在日常生活功能的七个领域中,参与者通常在主要活动(工作或学校)和休闲娱乐方面受到最大的干扰。受试者的整体功能状态随着时间的推移趋于改善,受伤后 3 个月内功能改善最为明显。然而,一些受试者即使在受伤后 12 个月仍继续报告功能受限。功能状态与神经认知功能基本无关,但与创伤后症状、生活满意度和情绪健康密切相关,尤其是在受伤后 3 个月及以后。
研究结果表明,mTBI 相关的功能障碍可能比普遍认为的更有可能持续存在,那些在特定时期持续存在功能缺陷的患者更容易出现情绪健康问题。