Shafique Muhammad Ashir, Mustafa Muhammad Saqlain, Kumar Aashish, Iqbal Javed, Haseeb Abdul, Rahman Hafsah Alim Ur, Mussarat Abdullah, Rangwala Burhanuddin Sohail, Rangwala Hussain Sohail, Ali Syed Muhammad Sinaan, Ashraf Mohammad
Department of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan.
Department of Medicine, Shaheed Mohtarma Benazir Bhutto Medical College, Karachi, Pakistan.
Asian J Neurosurg. 2024 Dec 12;20(1):20-33. doi: 10.1055/s-0044-1800952. eCollection 2025 Mar.
Traumatic brain injury (TBI) poses a significant public health challenge in the United States, with diverse causes and outcomes. Understanding the trends in TBI-related mortality is crucial for effective prevention and intervention strategies. This comprehensive analysis utilized data from the (CDC WONDER) database, covering the period from 1999 to 2020. Cause-of-death records were examined using the 10th Edition of the International Classification of Diseases and Related Health Problems diagnostic code S06 for TBI-related fatalities. Mortality rates were calculated per 100,000 individuals, adjusted for age and urban/rural status. Joinpoint Regression analysis was employed to identify significant trends over time. Between 1999 and 2020, 1,218,667 TBI-related deaths occurred, with varying mortality rates across demographic groups and geographic regions. Within the overall population, the highest annual average mortality rates were observed in the non-Hispanic (NH) American Indian or Alaska Native cohort, followed by NH white, NH black or African American, Hispanic or Latino, and NH Asian or Pacific Islander groups. Overall, there was an initial decrease in mortality rate from 1999 to 2012, followed by a subsequent significant increase. Males consistently exhibited higher mortality rates than females across all age groups. Disparities were also observed based on race/ethnicity, with NH American Indian or Alaska Native populations showing the highest mortality rates. Regional variations were evident, with the southern region consistently exhibiting the highest mortality rates. Evolving trends in TBI-related mortality in the United States highlight the need for targeted interventions, particularly in high-risk demographic groups and regions.
创伤性脑损伤（TBI）在美国构成了重大的公共卫生挑战，其病因和后果多种多样。了解与TBI相关的死亡率趋势对于有效的预防和干预策略至关重要。这项全面分析利用了疾病控制与预防中心（CDC）的WONDER数据库中的数据，涵盖了1999年至2020年期间。使用《国际疾病和相关健康问题统计分类》第10版的诊断代码S06对与TBI相关的死亡原因记录进行了检查。按每10万人计算死亡率，并根据年龄和城乡状况进行了调整。采用连接点回归分析来确定随时间的显著趋势。1999年至2020年期间，发生了1,218,667例与TBI相关的死亡，不同人口群体和地理区域的死亡率各不相同。在总体人群中，非西班牙裔（NH）美国印第安人或阿拉斯加原住民队列的年平均死亡率最高，其次是NH白人、NH黑人或非裔美国人、西班牙裔或拉丁裔以及NH亚裔或太平洋岛民群体。总体而言，1999年至2012年死亡率最初有所下降，随后显著上升。在所有年龄组中，男性的死亡率始终高于女性。基于种族/民族也观察到了差异，NH美国印第安人或阿拉斯加原住民群体的死亡率最高。区域差异明显，南部地区的死亡率始终最高。美国与TBI相关的死亡率的演变趋势凸显了有针对性干预措施的必要性，特别是在高风险人口群体和地区。
