Reproductive Health Research Center, Tehran University of Medical Science, Tehran, Iran.
Department of Gynecology & Obstetrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
J Cell Physiol. 2019 Aug;234(8):12301-12308. doi: 10.1002/jcp.28009. Epub 2019 Jan 4.
Interstitial cystitis/painful bladder syndrome (IC/PBS) is a chronic bladder inflammation that leads to chronic bladder pain and urinary urgency and frequency. The presentation of IC/PBS is heterogeneous, and it is classified as ulcerative IC/PBS and nonulcerative IC/PBS. The main cause of IC/PBS is thought to be a persistent inflammatory condition in the bladder, though the actual pathophysiology has not been identified yet. Although the underlying pathophysiology of IC/PBS is not completely understood, several theories for the etiology of this syndrome have been suggested, including deficiency of the glycosaminoglycan covering urothelium surface that results in leaky urothelium infection, immunological etiology, activated mast cells, neural changes, and inflammation. In addition, there are no gold standards for the detection of this disorder to date. So, determination of gene expression and its role in different signaling pathways in the pathogenesis of this heterogeneous disorder contribute to the more efficient cognition of the pathophysiology of this disease and to the design of effective treatments and molecular diagnostic methods for IC/PBS.
间质性膀胱炎/膀胱疼痛综合征（IC/PBS）是一种慢性膀胱炎症，可导致慢性膀胱疼痛以及尿急和尿频。IC/PBS 的表现具有异质性，可分为溃疡性 IC/PBS 和非溃疡性 IC/PBS。目前认为 IC/PBS 的主要原因是膀胱内持续存在炎症状态，但尚未确定其实际病理生理学。尽管 IC/PBS 的潜在病理生理学尚未完全了解，但已经提出了几种关于该综合征病因的理论，包括覆盖尿路上皮表面的糖胺聚糖缺失导致尿路上皮通透性增加、感染、免疫病因、活化的肥大细胞、神经变化和炎症。此外，迄今为止，还没有用于该疾病检测的金标准。因此，确定基因表达及其在不同信号通路中的作用，有助于更有效地认识这种异质性疾病的病理生理学，并为 IC/PBS 设计有效的治疗和分子诊断方法。
