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癌症分子诊断在液体活检中的临床应用

[Clinical Application of Cancer Molecular Diagnostics with Liquid Biopsy].

作者信息

Kubota Mamoru

出版信息

Rinsho Byori. 2016 Oct;64(10):1156-1162.

Abstract

"Liquid biopsy" is one of the hottest topics in the cancer molecular diagnostics field because of its potential to replace conventional tissue biopsy. "BEAMing" is one of the digital PCR platform technologies for liquid biopsy samples, and it features a high enough sensitivity to detect a very low concentration of mutation frag- ments in circulating tumor DNA from the plasma of cancer patients. In this article, some of the promising clinical applications of BEAMing technology and its future possibilities as an advanced cancer diagnostic will be briefly summarized. [Review].

摘要

“液体活检”因其有望取代传统组织活检的潜力,成为癌症分子诊断领域最热门的话题之一。“BEAMing”是用于液体活检样本的数字PCR平台技术之一,其特点是灵敏度高,足以检测癌症患者血浆中循环肿瘤DNA中极低浓度的突变片段。本文将简要总结BEAMing技术一些有前景的临床应用及其作为先进癌症诊断方法的未来可能性。[综述]

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