儿童实体瘤中循环肿瘤 DNA 的评估：液体活检的前景。
Assessment of circulating tumor DNA in pediatric solid tumors: The promise of liquid biopsies.
机构信息
Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.
Department of Oncology for Children and Adolescents, Gustave Roussy, Villejuif, France.
出版信息
Pediatr Blood Cancer. 2019 May;66(5):e27595. doi: 10.1002/pbc.27595. Epub 2019 Jan 6.
Abstract
Circulating tumor DNA can be detected in the blood and body fluids of patients using ultrasensitive technologies, which have the potential to improve cancer diagnosis, risk stratification, noninvasive tumor profiling, and tracking of treatment response and disease recurrence. As we begin to apply "liquid biopsy" strategies in children with cancer, it is important to tailor our efforts to the unique genomic features of these tumors and address the technical and logistical challenges of integrating biomarker testing. This article reviews the literature demonstrating the feasibility of applying liquid biopsy to pediatric solid malignancies and suggests new directions for future studies.
摘要
循环肿瘤 DNA 可以使用超敏技术在患者的血液和体液中检测到，这有可能改善癌症诊断、风险分层、非侵入性肿瘤分析以及治疗反应和疾病复发的跟踪。当我们开始在患有癌症的儿童中应用“液体活检”策略时，重要的是要根据这些肿瘤的独特基因组特征调整我们的努力，并解决整合生物标志物检测的技术和后勤挑战。本文综述了文献中证明液体活检在儿科实体恶性肿瘤中应用的可行性，并为未来的研究提出了新的方向。
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