基于适配体的诊断与治疗
Aptamer-Based Diagnostics and Therapeutics.
作者信息
Shigdar Sarah
机构信息
School of Medicine Deakin University, Geelong, Victoria 3128, Australia.
Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria 3128, Australia.
出版信息
Pharmaceuticals (Basel). 2019 Jan 2;12(1):6. doi: 10.3390/ph12010006.
Abstract
Aptamers were first described almost 30 years ago, with the publication of three separate research papers describing how a randomized library of RNA sequences could be incubated with a target to find a sequence that specifically binds via van der Waals forces, covalent and hydrogen bonding, and not Watson Crick base pairing [...].
摘要
适配体最早在近30年前被描述，当时发表了三篇独立的研究论文，阐述了如何将一个随机的RNA序列文库与一个靶标一起孵育，以找到一个通过范德华力、共价键和氢键而非沃森-克里克碱基配对特异性结合的序列[……]
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