Department of Microbiology, The University of Chicago, Chicago, IL 60637, USA.
Department of Microbiology, The University of Chicago, Chicago, IL 60637, USA.
Trends Immunol. 2019 Feb;40(2):81-83. doi: 10.1016/j.it.2018.12.005. Epub 2019 Jan 1.
Aberrant expression of T cell-resident programmed cell death protein-1 (PD-1) is known to promote tumor progression. A recent study (Nature 2018;564:130-135) has now identified the E3 ubiquitin ligase FBXO38 as a crucial regulator of PD-1 protein turnover in T cells, providing a novel mechanism for potential use in cancer immunotherapy.
已知 T 细胞驻留程序性细胞死亡蛋白-1（PD-1）的异常表达可促进肿瘤进展。最近的一项研究（《自然》2018 年；564：130-135）现已确定 E3 泛素连接酶 FBXO38 是 T 细胞中 PD-1 蛋白降解的关键调节因子，为癌症免疫治疗的潜在应用提供了新的机制。
