Department of Chemistry and Institutes of Biomedical Sciences, Collaborative Innovation Center of Genetics and Development, Fudan University, Shanghai, 200433, China.
The Institute for Translational Nanomedicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China; Central Laboratory, First Affiliated Hospital, Institute (college) of Integrative Medicine, Dalian Medical University, Dalian, 116021, China.
Biomaterials. 2019 Mar;195:51-62. doi: 10.1016/j.biomaterials.2018.12.029. Epub 2018 Dec 28.
Carbon monoxide (CO) gas therapy combined with chemotherapy and photothermal therapy (PTT) is a promising treatment mode for malignant tumor. Herein, we firstly reported doxorubicin (DOX) loaded Mn carbonyl modified Fe (Ⅲ)-based nanoMOFs (MIL-100) coated PEGylated magnetic carbon nanoparticles (denoted as MCM@PEG-CO-DOX NPs) as theranostics nanoplatforms for near-infrared (NIR)-responded CO-DOX combination therapy. MIL-100 as a good nanocarrier of DOX with high loading capacity can also chelate the Mn carbonyl after a smart modification. Meanwhile, magnetic carbon core possessed photothermal effect, which can convert the NIR light to heat by an 808 nm laser irradiation, resulting in the on-demand release of CO and DOX. As a result, combining with PTT, MCM@PEG-CO-DOX NPs killed tumor efficiently. Moreover, our synthesized MCM@PEG-CO-DOX NPs were capable of realizing tumor dual-mode imaging including magnetic resonance imaging (MRI) and photoacoustic imaging (PAI).
一氧化碳（CO）气体治疗联合化疗和光热治疗（PTT）是一种有前途的恶性肿瘤治疗模式。在此，我们首次报道了载多柔比星（DOX）的锰羰基修饰的 Fe（Ⅲ）基纳米 MOFs（MIL-100）包覆的聚乙二醇化磁性碳纳米粒子（表示为 MCM@PEG-CO-DOX NPs）作为用于近红外（NIR）响应 CO-DOX 联合治疗的治疗学纳米平台。MIL-100 作为 DOX 的一种良好的纳米载体，具有高载药能力，经过智能修饰后还可以螯合锰羰基。同时，磁性碳核具有光热效应，可通过 808nm 激光照射将 NIR 光转化为热，从而按需释放 CO 和 DOX。结果，MCM@PEG-CO-DOX NPs 联合 PTT 有效地杀死了肿瘤。此外，我们合成的 MCM@PEG-CO-DOX NPs 能够实现肿瘤的双模式成像，包括磁共振成像（MRI）和光声成像（PAI）。
