Pulmonary Rehabilitation Unit, ICS Maugeri SPA, IRCCS, Benevento, Italy.
Pulmonary Rehabilitation Unit, ICS Maugeri SPA, IRCCS, Benevento, Italy.
Adv Clin Chem. 2019;88:121-149. doi: 10.1016/bs.acc.2018.10.002. Epub 2018 Nov 22.
Chronic respiratory diseases (CRDs) are complex multifactorial disorders involving the airways and other lung structures. The development of reliable markers for an early and accurate diagnosis, including disease phenotype, and prediction of the response and/or adherence to treatment prescribed are essential points for the correct management of CRDs. Beside the traditional techniques to detect biomarkers, "omics" sciences have stimulated interest in clinical field as they could potentially improve the study of disease phenotype. Perturbations in a variety of metabolic and signaling pathways could contribute an understanding of CRDs pathogenesis. In particular, metabolomics provides powerful tools to map biological perturbations and their relationship with disease pathogenesis. The exhaled breath condensate (EBC) is a natural matrix of the respiratory tract, and is well suited for metabolomics studies. In this article, we review the current state of metabolomics methodology applied to EBC in the study of CRDs.
慢性呼吸系统疾病（CRD）是一种复杂的多因素疾病，涉及气道和其他肺部结构。开发可靠的标志物来进行早期和准确的诊断，包括疾病表型，以及预测对规定治疗的反应和/或依从性，对于正确管理 CRD 至关重要。除了传统的生物标志物检测技术外，“组学”科学激发了人们对临床领域的兴趣，因为它们有可能改善疾病表型的研究。各种代谢和信号通路的紊乱可能有助于了解 CRD 的发病机制。代谢组学特别提供了强大的工具来绘制生物扰动及其与疾病发病机制的关系。呼出气冷凝物（EBC）是呼吸道的天然基质，非常适合代谢组学研究。在本文中，我们回顾了代谢组学方法在 CRD 研究中应用于 EBC 的现状。
