Wang Ran, Davis Michael D
Manchester University NHS Foundation Trust, Manchester, United Kingdom.
Division of Immunology, Immunity to Infection and Respiratory Medicine at the University of Manchester, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom.
Respir Care. 2024 Apr 22;69(5):613-620. doi: 10.4187/respcare.11651.
Exhaled breath contains an extensive reservoir of biomolecules. The collection of exhaled breath is noninvasive and low risk. Therefore, its testing is an appealing strategy for the discovery of biomarkers of respiratory diseases. In this concise review, we summarize the evidence of exhaled breath tests for airways diseases and respiratory infections. An overview of breath collection methods in both individuals who are spontaneously breathing and those receiving mechanical ventilation is outlined. We also highlight the challenges in exhaled breath testing and areas for future research.
呼出气体中含有大量的生物分子。收集呼出气体是非侵入性的且风险较低。因此，对其进行检测是发现呼吸系统疾病生物标志物的一种有吸引力的策略。在这篇简要综述中，我们总结了呼出气体检测用于气道疾病和呼吸道感染的证据。概述了自主呼吸个体和接受机械通气个体的呼气收集方法。我们还强调了呼出气体检测中的挑战以及未来研究的领域。
