Lee Jennifer Wing Yee, Bance Manohar Lal
Otology and Skull Base Unit, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB20QQ, UK.
Otology and Skull Base Unit, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB20QQ, UK.
Otolaryngol Clin North Am. 2019 Apr;52(2):231-242. doi: 10.1016/j.otc.2018.11.004. Epub 2019 Jan 3.
"Bone conduction implant devices rely on osseointegration of titanium implants with the underlying skull, characterized by endosseous healing and de-novo bone formation both surrounding and onto the implant surface. The key steps in osseointegration are the initial tissue response to implantation, peri-implant osteogenesis, and peri-implant bone remodeling. There is increasing evidence that osseointegration is primarily an immune-mediated process with the key players being the complement cascade and macrophages, which form part of the host innate immunity. Implant design and composition, patient systemic factors, surgical technique, and loading characteristics can all affect the success of osseointegration."
骨传导植入装置依靠钛植入物与下方颅骨的骨整合，其特征是植入物周围及表面的骨内愈合和新生骨形成。骨整合的关键步骤包括对植入的初始组织反应、种植体周围成骨以及种植体周围骨重塑。越来越多的证据表明，骨整合主要是一个免疫介导的过程，关键参与者是补体级联反应和巨噬细胞，它们是宿主固有免疫的一部分。植入物的设计和成分、患者的全身因素、手术技术以及负载特性都会影响骨整合的成功。
