衰老对骨-植入物界面内骨固定的影响。
Effects of Aging on Osteosynthesis at Bone-Implant Interfaces.
机构信息
Department of Orthopaedic Surgery, School of Medicine, Stanford University, Stanford, CA 94063, USA.
Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
出版信息
Biomolecules. 2023 Dec 30;14(1):52. doi: 10.3390/biom14010052.
Abstract
Joint replacement is a common surgery and is predominantly utilized for treatment of osteoarthritis in the aging population. The longevity of many of these implants depends on bony ingrowth. Here, we provide an overview of current techniques in osteogenesis (inducing bone growth onto an implant), which is affected by aging and inflammation. In this review we cover the biologic underpinnings of these processes as well as the clinical applications. Overall, aging has a significant effect at the cellular and macroscopic level that impacts osteosynthesis at bone-metal interfaces after joint arthroplasty; potential solutions include targeting prolonged inflammation, preventing microbial adhesion, and enhancing osteoinductive and osteoconductive properties.
摘要
关节置换是一种常见的手术，主要用于治疗老年人群中的骨关节炎。许多这些植入物的使用寿命取决于骨的向内生长。在这里，我们提供了对成骨术（将骨生长到植入物上）的当前技术的概述，该技术受老化和炎症的影响。在这篇综述中，我们涵盖了这些过程的生物学基础以及临床应用。总的来说，衰老在细胞和宏观水平上都有显著的影响，影响关节置换后骨-金属界面的骨合成；潜在的解决方案包括靶向延长炎症、防止微生物黏附以及增强诱导和传导成骨特性。
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Correction: Pius et al. Effects of Aging on Osteosynthesis at Bone-Implant Interfaces. 2024, , 52.更正：皮乌斯等人。衰老对骨-植入物界面骨合成的影响。2024年，，52。
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