Wiśniewski Marek, Bieniek Adam, Roszek Katarzyna, Czarnecka Joanna, Bolibok Paulina, Ferrer Pilar, da Silva Ivan, Terzyk Artur P
Faculty of Chemistry, Physicochemistry of Carbon Materials Research Group, Nicolaus Copernicus University in Toruń, Gagarin Street 7, 87-100 Toruń, Poland.
Department of Biochemistry, Faculty of Biology and Environmental Protection, Nicolaus Copernicus University in Toruń, Lwowska 1, 87-100 Toruń, Poland.
ACS Med Chem Lett. 2018 Nov 19;9(12):1280-1284. doi: 10.1021/acsmedchemlett.8b00468. eCollection 2018 Dec 13.
Reactive oxygen species, contributing to oxidant-antioxidant imbalance, initiate damage to the airways cells, inflammatory processes, and further pathophysiological effects. Enhancing antioxidant properties is the main prophylactic and therapeutic challenge. In this work, a newly synthesized and biocompatible structure of the metal-biomolecule frameworks (MBioF) harnessing cystine as a linker and magnesium as metal nodes is presented. This structure provides crucial sulfhydryl groups of cysteine, with antioxidant activity, released stepwise in the site of delivery. We prove that once released, the compounds of MBioF increase the intracellular level of cysteine and total antioxidative capability of airway cells. Presented MBioF structures offer new perspectives for clinical applications as therapeutics or preventatives maintaining the antioxidant-oxidant balance.
活性氧会导致氧化-抗氧化失衡，引发气道细胞损伤、炎症过程及进一步的病理生理效应。增强抗氧化特性是主要的预防和治疗挑战。在这项工作中，展示了一种新合成的、具有生物相容性的金属-生物分子框架（MBioF）结构，该结构利用胱氨酸作为连接体，镁作为金属节点。这种结构提供了具有抗氧化活性的半胱氨酸关键巯基，它们在递送部位逐步释放。我们证明，一旦释放，MBioF的化合物会增加气道细胞内半胱氨酸水平和总抗氧化能力。所展示的MBioF结构为作为维持抗氧化-氧化平衡的治疗剂或预防剂的临床应用提供了新的前景。
