Elbadry Rasha, Elazim Ahmed Abd, Mohamed Kazim, Issa Mamdouh, Ayyad Ali
Department of Neurosurgery, Neuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
Department of Radiology, Neuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
Surg Neurol Int. 2018 Dec 4;9:245. doi: 10.4103/sni.sni_235_18. eCollection 2018.
Cerebellopontine angle represents a complex anatomical area of the brain. A cerebellopontine angle lesion could be a vestibular schwannoma, meningioma, epidermoid cyst, or less likely, arachnoid cyst, metastasis, lower cranial nerves schwannoma, lipoma, hemangioma, paraganglioma, or vertebra-basilar dolichoectasia. Primary meningeal melanocytoma is a rare neoplasm, especially when it occurs at the cerebellopontine angle. Nevus of Ota (aka oculodermal melanocytosis) is a hyperpigmentation along the distribution of the ophthalmic and maxillary branches of trigeminal nerve; it occurs due to entrapment of melanocytes at the upper third of the dermis. It may not present at birth and may show up at puberty.
We describe a case of primary meningeal melanocytoma of the cerebellopontine angle associated with nevus of Ota in a 46-year-old male patient presented with 7-day history of left arm weakness and vertigo. Computed tomography and MRI showed right-sided cerebellopontine angle mass, which was resected. Histopathology confirmed the meningeal melanocytic lesion and revealed its nature.
Primary meningeal melanocytoma of the brain is a rare but benign tumor; the association between meningeal melanocytoma and nevus of Ota is also rare and possibly explained by their common embryonic origin from neural crest cells. There are six cases reported so far in literature including our case for meningeal melanocytoma associated with nevus of Ota.
桥小脑角是大脑中一个复杂的解剖区域。桥小脑角病变可能是前庭神经鞘瘤、脑膜瘤、表皮样囊肿，较少见的有蛛网膜囊肿、转移瘤、低位颅神经鞘瘤、脂肪瘤、血管瘤、副神经节瘤或椎基底动脉迂曲扩张。原发性脑膜黑素细胞瘤是一种罕见的肿瘤，尤其是发生在桥小脑角时。太田痣（又称眼皮肤黑素细胞增多症）是沿三叉神经眼支和上颌支分布的色素沉着；它是由于黑素细胞被困在真皮上三分之一处而发生的。它可能在出生时不出现，而在青春期出现。
我们描述了一例46岁男性患者，其患有与太田痣相关的桥小脑角原发性脑膜黑素细胞瘤，患者有7天左臂无力和眩晕病史。计算机断层扫描和磁共振成像显示右侧桥小脑角肿块，予以切除。组织病理学证实了脑膜黑素细胞病变并揭示了其性质。
脑原发性脑膜黑素细胞瘤是一种罕见的良性肿瘤；脑膜黑素细胞瘤与太田痣之间的关联也很罕见，可能是由于它们共同起源于神经嵴细胞的胚胎发育。迄今为止，文献中报道了6例包括我们的病例在内的与太田痣相关的脑膜黑素细胞瘤。
