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Treatment of acquired drug resistance in multiple myeloma by combination therapy with XPO1 and topoisomerase II inhibitors.采用XPO1与拓扑异构酶II抑制剂联合疗法治疗多发性骨髓瘤获得性耐药
J Hematol Oncol. 2016 Aug 24;9(1):73. doi: 10.1186/s13045-016-0304-z.
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Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Combination With Fludarabine and Cytarabine, in Pediatric Relapsed or Refractory Acute Leukemia.核输出选择性抑制剂塞利尼索联合氟达拉滨和阿糖胞苷治疗儿童复发或难治性急性白血病的I期研究
J Clin Oncol. 2016 Dec;34(34):4094-4101. doi: 10.1200/JCO.2016.67.5066. Epub 2016 Oct 31.
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First-in-Class, First-in-Human Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Patients With Advanced Solid Tumors.塞利尼索（一种核输出选择性抑制剂）在晚期实体瘤患者中的首例人体I期研究，该研究为同类首创。
J Clin Oncol. 2016 Dec;34(34):4142-4150. doi: 10.1200/JCO.2015.65.3949. Epub 2016 Oct 31.
5
Nuclear Export as a Novel Therapeutic Target: The CRM1 Connection.作为新型治疗靶点的核输出：与CRM1的联系
Curr Cancer Drug Targets. 2015;15(7):575-92. doi: 10.2174/156800961507150828223554.
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Epigallocatechin-3-gallate enhances the therapeutic effects of leptomycin B on human lung cancer a549 cells.表没食子儿茶素-3-没食子酸酯增强了雷帕霉素对人肺癌A549细胞的治疗效果。
Oxid Med Cell Longev. 2015;2015:217304. doi: 10.1155/2015/217304. Epub 2015 Apr 1.
7
Overexpression of CRM1: A Characteristic Feature in a Transformed Phenotype of Lung Carcinogenesis and a Molecular Target for Lung Cancer Adjuvant Therapy.CRM1 过表达：肺癌发生转化表型的特征性特征，也是肺癌辅助治疗的分子靶点。
J Thorac Oncol. 2015 May;10(5):815-825. doi: 10.1097/JTO.0000000000000485.
8
Chemotherapeutic sensitization of leptomycin B resistant lung cancer cells by pretreatment with doxorubicin.多柔比星预处理增敏耐博霉素 B 肺癌细胞的化疗作用。
PLoS One. 2012;7(3):e32895. doi: 10.1371/journal.pone.0032895. Epub 2012 Mar 7.
9
CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity.CBS9106 是一种新型的可逆口服 CRM1 抑制剂，具有 CRM1 降解活性。
Blood. 2011 Oct 6;118(14):3922-31. doi: 10.1182/blood-2011-01-333138. Epub 2011 Aug 12.
10
CRM1-dependent p53 nuclear accumulation in lung lesions of a bitransgenic mouse lung tumor model.CRM1 依赖性 p53 核积累在双转基因小鼠肺肿瘤模型肺病变中。
Oncol Rep. 2011 Jul;26(1):223-8. doi: 10.3892/or.2011.1279. Epub 2011 Apr 21.

Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer.

作者信息

Gao Weimin

机构信息

Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock, Texas, USA.

出版信息

Transl Cancer Res. 2017 Feb;6(Suppl 1):S83-S86. doi: 10.21037/tcr.2017.02.35.

DOI:10.21037/tcr.2017.02.35
PMID:30613477
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6319890/
Abstract
摘要