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JAK-STAT-mediated chronic inflammation impairs cytotoxic T lymphocyte activation to decrease anti-PD-1 immunotherapy efficacy in pancreatic cancer.JAK-STAT介导的慢性炎症会损害细胞毒性T淋巴细胞的激活，从而降低抗PD-1免疫疗法在胰腺癌中的疗效。
Oncoimmunology. 2017 Feb 10;6(3):e1291106. doi: 10.1080/2162402X.2017.1291106. eCollection 2017.
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The MLL1-H3K4me3 Axis-Mediated PD-L1 Expression and Pancreatic Cancer Immune Evasion.MLL1-H3K4me3轴介导的PD-L1表达与胰腺癌免疫逃逸
J Natl Cancer Inst. 2017 Jan 28;109(6). doi: 10.1093/jnci/djw283. Print 2017 Jan.
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Deubiquitination and Stabilization of PD-L1 by CSN5.CSN5介导的PD-L1去泛素化及稳定性维持
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Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial.帕博利珠单抗对比多西他赛用于治疗后 PD-L1 阳性的、晚期非小细胞肺癌（KEYNOTE-010）：一项随机对照试验。
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H3K9 Trimethylation Silences Fas Expression To Confer Colon Carcinoma Immune Escape and 5-Fluorouracil Chemoresistance.H3K9三甲基化使Fas表达沉默，从而导致结肠癌免疫逃逸和5-氟尿嘧啶化疗耐药。
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Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer.纳武单抗与多西他赛治疗晚期鳞状细胞非小细胞肺癌的疗效比较
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The role of CD95 and CD95 ligand in cancer.CD95和CD95配体在癌症中的作用。
Cell Death Differ. 2015 May;22(5):885-6. doi: 10.1038/cdd.2015.25.
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Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic Carcinoma.诱导 T 细胞免疫克服对 PD-1 和 CTLA-4 阻断的完全抵抗并改善胰腺癌患者的生存。
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Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients.癌症患者对抗PD-L1抗体MPDL3280A反应的预测性相关因素。
Nature. 2014 Nov 27;515(7528):563-7. doi: 10.1038/nature14011.

Epigenetic regulation of PD-L1 expression and pancreatic cancer response to checkpoint immunotherapy.

作者信息

Lu Chunwan, Liu Kebin

机构信息

Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA, USA.

Georgia Cancer Center, Augusta University, Augusta, GA, USA.

出版信息

Transl Cancer Res. 2017 May;6(Suppl 3):S652-S654. doi: 10.21037/tcr.2017.05.32.

DOI:10.21037/tcr.2017.05.32
PMID:30613482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6320224/
Abstract
摘要