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HLA-B*58:01 is not the only risk factor associated with allopurinol-induced severe cutaneous adverse drug reactions.HLA - B*58:01并非与别嘌醇诱导的严重皮肤药物不良反应相关的唯一风险因素。
Ann Transl Med. 2018 Nov;6(Suppl 1):S7. doi: 10.21037/atm.2018.08.42.
2
Impact of the HLA-B(*)58:01 Allele and Renal Impairment on Allopurinol-Induced Cutaneous Adverse Reactions.HLA - B(*)58:01等位基因及肾功能损害对别嘌醇诱导的皮肤不良反应的影响
J Invest Dermatol. 2016 Jul;136(7):1373-1381. doi: 10.1016/j.jid.2016.02.808. Epub 2016 Mar 18.
3
Efficacy of the HLA-B58:01 Screening Test in Preventing Allopurinol-Induced Severe Cutaneous Adverse Reactions in Patients with Chronic Renal Insufficiency-A Prospective Study.HLA-B58:01 筛查试验预防慢性肾功能不全患者别嘌醇诱导的严重皮肤不良反应的疗效：一项前瞻性研究。
J Allergy Clin Immunol Pract. 2019 Apr;7(4):1271-1276. doi: 10.1016/j.jaip.2018.12.012. Epub 2018 Dec 21.
4
HLA-B*58:01 allele is associated with augmented risk for both mild and severe cutaneous adverse reactions induced by allopurinol in Han Chinese.HLA-B*58:01 等位基因与汉族人群别嘌醇诱导的轻中度和重度皮肤不良反应风险增加相关。
Pharmacogenomics. 2012 Jul;13(10):1193-201. doi: 10.2217/pgs.12.89.
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Allopurinol-induced severe cutaneous adverse reactions: A report of three cases with the allele who underwent lymphocyte activation test.别嘌醇诱导的严重皮肤不良反应：3例携带该等位基因患者接受淋巴细胞活化试验的报告。
Transl Clin Pharmacol. 2017 Jun;25(2):63-66. doi: 10.12793/tcp.2017.25.2.63. Epub 2017 Jun 15.
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The Presence of HLA-B75, DR13 Homozygosity, or DR14 Additionally Increases the Risk of Allopurinol-Induced Severe Cutaneous Adverse Reactions in HLA-B*58:01 Carriers.HLA-B*58:01 携带者存在 HLA-B75、DR13 纯合子或 DR14 时，会增加别嘌醇诱导的严重皮肤不良反应的风险。
J Allergy Clin Immunol Pract. 2019 Apr;7(4):1261-1270. doi: 10.1016/j.jaip.2018.11.039. Epub 2018 Dec 7.
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Genotyping HLA-B*5801 for Allopurinol-Induced Severe Cutaneous Adverse Reactions: An Accurate and Prompt Method.通过基因分型HLA - B*5801预测别嘌醇诱导的严重皮肤不良反应：一种准确且快速的方法。
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Use of HLA-B*58:01 genotyping to prevent allopurinol induced severe cutaneous adverse reactions in Taiwan: national prospective cohort study.台湾地区使用HLA - B*58:01基因分型预防别嘌醇所致严重皮肤不良反应的全国前瞻性队列研究
BMJ. 2015 Sep 23;351:h4848. doi: 10.1136/bmj.h4848.
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Validation of a Rapid, Robust, Inexpensive Screening Method for Detecting the HLA-B*58:01 Allele in the Prevention of Allopurinol-Induced Severe Cutaneous Adverse Reactions.一种快速、可靠、廉价的检测HLA - B*58:01等位基因的筛查方法在预防别嘌醇诱导的严重皮肤不良反应中的验证
Allergy Asthma Immunol Res. 2017 Jan;9(1):79-84. doi: 10.4168/aair.2017.9.1.79.
10
Genetic markers associated with cutaneous adverse drug reactions to allopurinol: a systematic review.与别嘌醇皮肤不良反应相关的遗传标志物：一项系统综述。
Pharmacogenomics. 2015;16(7):755-67. doi: 10.2217/pgs.15.21. Epub 2015 May 12.

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Allopurinol-Induced Stevens-Johnson Syndrome in Javanese Men With Positive HLA-B*58:01.HLA - B*58:01阳性的爪哇男性中别嘌醇诱发的史蒂文斯-约翰逊综合征
Front Genet. 2022 Jun 13;13:839154. doi: 10.3389/fgene.2022.839154. eCollection 2022.
2
HLA-B*58:01 screening to prevent allopurinol-induced severe cutaneous adverse reactions in Chinese patients with chronic kidney disease.HLA-B*58:01 筛查可预防中国慢性肾脏病患者使用别嘌醇所致的严重皮肤不良反应。
Arch Dermatol Res. 2022 Sep;314(7):651-659. doi: 10.1007/s00403-021-02258-3. Epub 2021 Jul 2.
3
The genetic contribution of and to Posner-Schlossman syndrome in southern Chinese.α和β对中国南方波斯纳-施洛斯曼综合征的遗传贡献。
Ann Transl Med. 2019 Dec;7(23):749. doi: 10.21037/atm.2019.11.70.

本文引用的文献

1
Racial/ethnic variation and risk factors for allopurinol-associated severe cutaneous adverse reactions: a cohort study.种族/民族差异与别嘌醇相关性严重皮肤不良反应的危险因素：一项队列研究。
Ann Rheum Dis. 2018 Aug;77(8):1187-1193. doi: 10.1136/annrheumdis-2017-212905. Epub 2018 Apr 13.
2
HLAs: Key regulators of T-cell-mediated drug hypersensitivity.人类白细胞抗原：T 细胞介导的药物超敏反应的关键调节因子。
HLA. 2018 Jan;91(1):3-16. doi: 10.1111/tan.13183.
3
Tailoring of recommendations to reduce serious cutaneous adverse drug reactions: a pharmacogenomics approach.调整用药建议以减少严重皮肤药物不良反应：一种药物基因组学方法。
Pharmacogenomics. 2017 Jun;18(9):881-890. doi: 10.2217/pgs-2017-0016. Epub 2017 Jun 8.
4
Severe Delayed Cutaneous and Systemic Reactions to Drugs: A Global Perspective on the Science and Art of Current Practice.药物引起的严重迟发性皮肤和全身反应：当前实践科学与艺术的全球视角
J Allergy Clin Immunol Pract. 2017 May-Jun;5(3):547-563. doi: 10.1016/j.jaip.2017.01.025.
5
Cost-effectiveness Analysis for Genotyping before Allopurinol Treatment to Prevent Severe Cutaneous Adverse Drug Reactions.别嘌醇治疗前基因分型预防严重皮肤药物不良反应的成本效益分析
J Rheumatol. 2017 Jun;44(6):835-843. doi: 10.3899/jrheum.151476. Epub 2017 Apr 1.
6
HLA-B (*) 58:01 for Allopurinol-Induced Cutaneous Adverse Drug Reactions: Implication for Clinical Interpretation in Thailand.别嘌醇所致皮肤不良反应的HLA - B (*) 58:01：对泰国临床解读的意义
Front Pharmacol. 2016 Jul 18;7:186. doi: 10.3389/fphar.2016.00186. eCollection 2016.
7
Immunopathogenesis and risk factors for allopurinol severe cutaneous adverse reactions.别嘌醇严重皮肤不良反应的免疫发病机制及危险因素
Curr Opin Allergy Clin Immunol. 2016 Aug;16(4):339-45. doi: 10.1097/ACI.0000000000000286.
8
Insights into the poor prognosis of allopurinol-induced severe cutaneous adverse reactions: the impact of renal insufficiency, high plasma levels of oxypurinol and granulysin.别嘌醇诱导的严重皮肤不良反应预后不良的原因分析：肾功能不全、高血浆氧嘌呤醇水平和粒酶的影响。
Ann Rheum Dis. 2015 Dec;74(12):2157-64. doi: 10.1136/annrheumdis-2014-205577. Epub 2014 Aug 12.
9
HLA-B*58:01 is a risk factor for allopurinol-induced DRESS and Stevens-Johnson syndrome/toxic epidermal necrolysis in a Portuguese population.HLA-B*58:01 是葡萄牙人群中别嘌醇诱导的 DRESS 和 Stevens-Johnson 综合征/中毒性表皮坏死松解症的危险因素。
Br J Dermatol. 2013 Sep;169(3):660-5. doi: 10.1111/bjd.12389.
10
HLA-B*58:01 allele is associated with augmented risk for both mild and severe cutaneous adverse reactions induced by allopurinol in Han Chinese.HLA-B*58:01 等位基因与汉族人群别嘌醇诱导的轻中度和重度皮肤不良反应风险增加相关。
Pharmacogenomics. 2012 Jul;13(10):1193-201. doi: 10.2217/pgs.12.89.

HLA-B*58:01 is not the only risk factor associated with allopurinol-induced severe cutaneous adverse drug reactions.

作者信息

Gonçalo Margarida

机构信息

Clinic of Dermatology, University Hospital and Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

出版信息

Ann Transl Med. 2018 Nov;6(Suppl 1):S7. doi: 10.21037/atm.2018.08.42.

DOI:10.21037/atm.2018.08.42
PMID:30613583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6291593/
Abstract
摘要