Tanaka K, Fukuda S, Terayama Y, Toriyama M, Ishidoya J, Ito Y, Sugiura A
Department of Otolaryngology, Hokkaido University School of Medicine, Sapporo, Japan.
Auris Nasus Larynx. 1988;15(2):89-96. doi: 10.1016/s0385-8146(88)80013-0.
Three monkeys (Macaca irus) were inoculated with mumps virus into unilateral cochleas and their inner ear were examined by immunofluorescent microscopy and transmission electronmicroscopy. The temporal bones were removed after survival period of 14 days when serological tests disclosed elevation of anti-mumps antibody titers. Immunofluorescent microscopy revealed that the viral antigen was positive in the stria vascularis. The ultrastructural study revealed that the pathologic changes in the cochleas were marked in the organ of Corti and stria vascularis. The outer hair cells were more susceptible to the infection than the inner hair cells. In the stria vascularis, both marginal and intermediate cells were affected. It was possible to find some of marginal cells in the basal turn shedding a large number of mature virions into the endolymph. These pathologic changes observed in the cochleas of the monkeys were similar to those previously revealed in the guinea pig cochleas and thus were considered as the specific features of acute mumps labyrinthitis.
将三只食蟹猴（猕猴属）的单侧耳蜗接种腮腺炎病毒，并通过免疫荧光显微镜和透射电子显微镜检查它们的内耳。在14天的存活期后取出颞骨，此时血清学检测显示抗腮腺炎抗体滴度升高。免疫荧光显微镜检查显示，血管纹中的病毒抗原呈阳性。超微结构研究显示，耳蜗的病理变化在柯蒂器和血管纹中较为明显。外毛细胞比内毛细胞更容易受到感染。在血管纹中，边缘细胞和中间细胞均受到影响。在基底转可以发现一些边缘细胞将大量成熟病毒粒子排入内淋巴。在猴耳蜗中观察到的这些病理变化与先前在豚鼠耳蜗中发现的变化相似，因此被认为是急性腮腺炎迷路炎的特征。
