Nomura Y, Harada T, Hara M
Department of Otolaryngology, University of Tokyo, Japan.
ORL J Otorhinolaryngol Relat Spec. 1988;50(4):201-11. doi: 10.1159/000275993.
The work of Japanese research committees on the relation of viral infection to sudden deafness and acute profound deafness is briefly introduced. The criteria for making a diagnosis of sudden deafness and mumps deafness are described. A new method of detecting IgM antibody to mumps virus was developed in research done for one of the committees. Use of this method revealed that sudden deafness in 1 out of 39 patients was due to mumps virus. Experimental viral labyrinthitis was produced in guinea pigs using herpes simplex virus (types 1 and 2) and guinea pig cytomegalovirus (GPCMV). Histopathological studies were conducted, and the results are discussed and compared with those for human viral labyrinthitis. Anomaly of the cochlea was found in the offspring of a guinea pig which became pregnant just after GPCMV was inoculated into its cochlea.
简要介绍了日本研究委员会关于病毒感染与突发性耳聋和急性重度耳聋关系的研究工作。描述了突发性耳聋和腮腺炎耳聋的诊断标准。在为其中一个委员会开展的研究中开发了一种检测腮腺炎病毒IgM抗体的新方法。使用该方法发现，39名患者中有1例突发性耳聋是由腮腺炎病毒引起的。利用单纯疱疹病毒（1型和2型）和豚鼠巨细胞病毒（GPCMV）在豚鼠身上诱发了实验性病毒性迷路炎。进行了组织病理学研究，并对结果进行了讨论，并与人类病毒性迷路炎的结果进行了比较。在一只豚鼠的耳蜗接种GPCMV后不久怀孕，其后代出现了耳蜗异常。
