Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, 100193, Beijing, People's Republic of China.
, Yuanmingyuan west road 2, 100193, Beijing, People's Republic of China.
Environ Sci Pollut Res Int. 2019 Feb;26(6):5804-5813. doi: 10.1007/s11356-018-4004-9. Epub 2019 Jan 6.
The widespread application of bisphenols (BPs) in the industry has made them ubiquitous in the environment, causing potential environmental risks. Its unknown impacts on human being have received more and more attention. In this study, we have assessed the metabolic effects of perinatal exposure to bisphenol A (BPA) and its substitutes (bisphenol S (BPS), bisphenol F (BPF), and bisphenol AF (BPAF)) in female mice adolescent offspring and female mice adulthood offspring. H NMR-based serum metabolomics showed that metabolic profiles were disturbed with BPA and its three substitutes exposure in female mice adolescent offspring and female mice adulthood offspring. In addition, age-related metabolic effects were found based on changes in serum endogenous metabolites and metabolic pathways. Specifically, metabolic pathway analysis showed that major disturbed metabolic pathways in female mice adulthood offspring compare with female mice adolescent offspring also changed significantly. With the increase of age of the female mice offspring, changes in the metabolic pathways became more obvious in the BPA treatment group. Conversely, partially disturbed metabolic pathways were restored in the BPS, BPF, and BPAF treatment groups. In conclusion, perinatal exposure to BPA and its three substitutes significantly interferes with metabolic profiles and metabolic pathways, and this metabolic effects were age-related. These results offer more detailed information about the age-related metabolic effects of perinatal exposure to BPA, BPS, BPF, and BPAF in female mice offspring and provide data for systematic evaluation of the health risk assessment of BPA and its substitutes.
双酚类物质（BPs）在工业中的广泛应用使其在环境中无处不在，造成了潜在的环境风险。其对人类的未知影响受到了越来越多的关注。在本研究中，我们评估了围产期暴露于双酚 A（BPA）及其替代品（双酚 S（BPS）、双酚 F（BPF）和双酚 AF（BPAF））对雌性小鼠青春期后代和成年后代的代谢影响。基于氢核磁共振（1H NMR）的血清代谢组学表明，BPA 及其三种替代品暴露会扰乱雌性小鼠青春期后代和成年后代的代谢谱。此外，还发现了基于血清内源性代谢物和代谢途径变化的与年龄相关的代谢效应。具体而言，代谢途径分析表明，与雌性小鼠青春期后代相比，雌性小鼠成年后代中主要受干扰的代谢途径也发生了显著变化。随着雌性小鼠后代年龄的增加，BPA 处理组的代谢途径变化更加明显。相反，BPS、BPF 和 BPAF 处理组部分受干扰的代谢途径得到了恢复。总之，围产期暴露于 BPA 及其三种替代品会显著干扰代谢谱和代谢途径，且这种代谢效应与年龄有关。这些结果为雌性小鼠后代围产期暴露于 BPA、BPS、BPF 和 BPAF 的年龄相关代谢效应提供了更详细的信息，并为 BPA 及其替代品的健康风险评估提供了数据支持。
