Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, Beijing, 100193, China.
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, Beijing, 100193, China.
Environ Pollut. 2019 Apr;247:935-943. doi: 10.1016/j.envpol.2019.01.116. Epub 2019 Jan 30.
Bisphenols (BPs) are common environmental pollutants that are ubiquitous in the natural environment and can affect human health. In this study, we explored the effects of perinatal exposure to BPA, BPF and BPAF on liver function involving in oxidative damage and metabolic disorders in male mouse offspring. We found that BPA exposure impairs the antioxidant defense system, increases lipid peroxidation, and causes oxidative damage in the liver. Furthermore, the levels of 13 metabolites were significantly altered following BPA exposure. We found that BPF exposure significantly increased the expression and activity of CAT, suggesting disturbances in the antioxidant defense system. Moreover, BPF exposure led to metabolic disorders in the liver due to changes in the levels of 8 key metabolites. Exposure to BPAF caused no negative effects on oxidative damage, but altered the levels of β-glucose and glycogen. In summary, perinatal exposure to BPA, BPF and BPAF differentially influence oxidative damage and metabolic disorders in the livers of male mouse offspring. The impact of early life exposure to BPs now warrants future investigations.
双酚类物质（BPs）是常见的环境污染物，广泛存在于自然环境中，可能会影响人类健康。在本研究中，我们探讨了围产期暴露于 BPA、BPF 和 BPAF 对雄性小鼠后代肝功能的影响，这些影响涉及氧化损伤和代谢紊乱。我们发现，BPA 暴露会损害抗氧化防御系统，增加脂质过氧化，导致肝脏氧化损伤。此外，BPA 暴露还会显著改变 13 种代谢物的水平。我们发现，BPF 暴露会显著增加 CAT 的表达和活性，表明抗氧化防御系统受到干扰。此外，BPF 暴露会导致肝脏代谢紊乱，这是由于 8 种关键代谢物的水平发生了变化。BPAF 暴露对氧化损伤没有负面影响，但会改变β-葡萄糖和糖原的水平。总之，围产期暴露于 BPA、BPF 和 BPAF 会对雄性小鼠后代肝脏的氧化损伤和代谢紊乱产生不同的影响。早期生命接触 BPs 的影响现在需要进一步研究。
