Boldy D A, Lever L R, Unwin P R, Spencer P A, Hoare A M
Department of Medicine, Wycombe General Hospital, High Wycombe, Bucks.
Br J Anaesth. 1988 Dec;61(6):698-701. doi: 10.1093/bja/61.6.698.
One hundred patients received either diazepam given with pethidine, antagonized with naloxone, or midazolam alone in a double-blind randomized study of sedation for upper gastrointestinal endoscopy. Midazolam produced better amnesia for the procedure (P less than 0.0001) but diazepam and pethidine resulted in less retching during the procedure (P less than 0.01) and less sedation after the procedure, as judged by a simple performance test (P less than 0.02) and patient recall of results (P less than 0.02).
在一项关于上消化道内镜检查镇静的双盲随机研究中，100名患者分别接受了地西泮与哌替啶联用并以纳洛酮拮抗、或单独使用咪达唑仑的治疗。咪达唑仑对该操作产生了更好的遗忘效果（P<0.0001），但地西泮和哌替啶在操作过程中导致的干呕较少（P<0.01），且操作后镇静程度较轻，这通过一项简单的性能测试（P<0.02）和患者对结果的回忆（P<0.02）来判断。
