Yang Won-Kyung, Kim Seung-Hyung, Jung In Chul, Park Yang-Chun
1 Department of Internal Medicine, College of Korean Medicine, Daejeon University, Daejeon, Korea.
2 Institute of Traditional Medicine and Bioscience, Daejeon University, Daejeon, Korea.
J Med Food. 2019 Jan;22(1):87-96. doi: 10.1089/jmf.2018.4200. Epub 2019 Jan 7.
Chronic obstructive pulmonary disease (COPD), including pulmonary emphysema and chronic bronchitis as well as structural and inflammatory changes in small airways, is insensitive to corticosteroid therapies. This study aimed to evaluate the effects of Scutellaria baicalensis root extract (SB_E) in a mouse model of COPD. The COPD mouse model was produced by challenging C57BL/6 mice with a cigarette smoke extract and lipopolysaccharide (LPS). SB_E significantly decreased the neutrophil counts in blood and bronchoalveolar lavage fluid (BALF), and the production of tumor necrosis factor (TNF)-α, interleukin (IL)-17A, macrophage inflammatory protein 2 (MIP2), and chemokine (C-X-C motif) ligand 1 (CXCL-1) in BALF, and TNF-α mRNA expression in lung tissue. The histological lung injury was also alleviated by treatment with SB_E. Thus, SB_E effectively inhibited airway inflammation by regulating the expression of inflammatory cytokines by blocking MIP2 and CXCL-1 secretion. Therefore, S. baicalensis may be a potential therapeutic agent for COPD.
慢性阻塞性肺疾病（COPD），包括肺气肿、慢性支气管炎以及小气道的结构和炎症变化，对皮质类固醇疗法不敏感。本研究旨在评估黄芩根提取物（SB_E）在COPD小鼠模型中的作用。通过用香烟烟雾提取物和脂多糖（LPS）刺激C57BL/6小鼠建立COPD小鼠模型。SB_E显著降低了血液和支气管肺泡灌洗液（BALF）中的中性粒细胞计数，以及BALF中肿瘤坏死因子（TNF）-α、白细胞介素（IL）-17A、巨噬细胞炎性蛋白2（MIP2）和趋化因子（C-X-C基序）配体1（CXCL-1）的产生，以及肺组织中TNF-α mRNA的表达。SB_E治疗也减轻了肺组织学损伤。因此，SB_E通过阻断MIP2和CXCL-1分泌来调节炎性细胞因子的表达，从而有效抑制气道炎症。因此，黄芩可能是COPD的一种潜在治疗药物。
