Department of Gynecology, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510315, China.
Department of Dermatovenereology, Foshan Maternal and Child Health Hospital, Foshan, Guangdong 528000, China.
Cancer Biomark. 2019;24(2):213-221. doi: 10.3233/CBM-181849.
To investigate TCF4 expression in epithelial ovarian cancer, and to explore its correlation with clinicopathological parameters and clinical prognosis of epithelial ovarian cancer.
From 2009 to 2017, 188 cases of paraffin-embedded epithelial ovarian cancer tissues and 41 paratumor ovarian tissues which had been confirmed at the memorial hospital of Sun Yat-sen University were collected in this study, and the expression of TCF4 was performed by immunohistochemistry using a polyclonal antibody specific for TCF4.
The expression of TCF4 protein was associated with disease progression free survival and overall survival in epithelial ovarian cancer patients; and TCF4 overexpression was associated with age, FIGO stage, lymph node metastasis, intraperitoneal metastasis, intestinal metastasis, vital status, intraperitoneal recurrence, and serum CA153. Moreover, in a multivariate Cox regression analysis TCF4 overexpression was an indeed independent prognostic factor in epithelial ovarian cancer.
TCF4 may play an oncogenic role in epithelial ovarian cancer, and TCF4 is a useful independent prognostic biomarker of epithelial ovarian cancer, and it may provide a candidate target therapy treatment in future.
研究 TCF4 在卵巢上皮性癌中的表达情况，并探讨其与卵巢上皮性癌临床病理参数及预后的关系。
收集中山大学附属纪念医院 2009 年至 2017 年存档的 188 例石蜡包埋的卵巢上皮性癌组织和 41 例癌旁组织，应用 TCF4 多克隆抗体通过免疫组化法检测 TCF4 的表达。
在卵巢上皮性癌患者中，TCF4 蛋白的表达与无疾病进展生存和总生存相关；TCF4 过表达与年龄、FIGO 分期、淋巴结转移、腹腔转移、肠转移、生存状态、腹腔复发和血清 CA153 相关。此外，多因素 Cox 回归分析表明 TCF4 过表达是卵巢上皮性癌的独立预后因素。
TCF4 可能在上皮性卵巢癌中发挥致癌作用，TCF4 是上皮性卵巢癌有价值的独立预后标志物，可能为今后的靶向治疗提供候选治疗靶点。
