From the Cardiovascular Research Unit and Exercise Physiology, Federal University of Juiz de Fora, Juiz de Fora, Brazil (LBdA, PAdCM, PFT, MCL, DGM); Master's Program on Rehabilitation Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil (APF, CM, MCL, DGM); Department of Hematology, Hemotherapy and Bone Marrow Transplantation, Federal University of Juiz de Fora, Juiz de Fora, Brazil (AEHN); and Department of Clinical Medical, Federal University of Juiz de Fora, Juiz de Fora, Brazil (AEHN).
Am J Phys Med Rehabil. 2019 Jun;98(6):450-455. doi: 10.1097/PHM.0000000000001125.
The aim of the study was to compare the quality of life (QOL) of patients undergoing hematopoietic stem cell transplantation who improved their functional capacity during hospitalization (increased functional capacity group) with that of patients who maintained or decreased functional capacity during hospitalization (decreased functional capacity group).
This observational, longitudinal study included 27 hospitalized patients undergoing hematopoietic stem cell transplantation. Patients were divided into increased functional capacity group (16 patients) and decreased functional capacity group (11 patients). Functional capacity (6-min step test), peripheral muscle strength (sit-to-stand test and handgrip strength), and QOL (European Organization for Research and Treatment of Cancer) were assessed at admission and at hospital discharge.
Increased functional capacity patients had increased functional capacity and peripheral muscle strength of the lower and upper limbs at hospital discharge (P < 0.01, <0.01, and 0.02, respectively). The patients in the increased functional capacity group demonstrated an increase in global health and reduced symptoms at discharge (P = 0.02 and 0.03, respectively). No significant differences were observed between groups in the functional domain.
Patients undergoing hematopoietic stem cell transplantation, who have improved functional capacity at discharge, also experience an improved QOL, with no such improvement noted among patients who have stable or reduced functional capacity. We recommend that the treatment protocol for hospitalized patients undergoing hematopoietic stem cell transplantation include an exercise program aimed at improving functional capacity.
本研究旨在比较造血干细胞移植住院患者在住院期间功能能力改善（功能能力增加组）与功能能力保持或下降（功能能力下降组）患者的生活质量（QOL）。
这是一项观察性、纵向研究，纳入 27 例正在接受造血干细胞移植的住院患者。将患者分为功能能力增加组（16 例）和功能能力下降组（11 例）。在入院时和出院时评估功能能力（6 分钟踏步试验）、外周肌肉力量（坐站试验和握力）和 QOL（欧洲癌症研究与治疗组织）。
功能能力增加组患者在出院时的功能能力和上下肢外周肌肉力量均增加（P<0.01、<0.01 和 0.02）。功能能力增加组患者在出院时的总体健康状况和症状减轻（P=0.02 和 0.03）。两组在功能领域无显著差异。
造血干细胞移植住院患者在出院时功能能力改善，也会提高生活质量，而功能能力稳定或下降的患者则没有这种改善。我们建议造血干细胞移植住院患者的治疗方案应包括旨在提高功能能力的锻炼方案。
