Post-Graduation Program on Collective Health, Federal University of Juiz de Fora, Minas Gerais, Brazil.
Post-Graduation Program on Rehabilitation Sciences and Physical Function Performance, Federal University of Juiz de Fora, Minas Gerais, Brazil.
Disabil Rehabil. 2021 Feb;43(3):386-392. doi: 10.1080/09638288.2019.1626493. Epub 2019 Jun 11.
The purpose of this study is to evaluate the feasibility of an individualized exercise program for people undergoing hematopoietic stem cell transplantation.
This is a feasibility study of an individualized in-hospital exercise training program for people undergoing hematopoietic stem cell transplantation. Participants performed the exercise program based on daily clinical, hemodynamic and hematological assessment. The program was carried out on a daily basis for 20-40 min during their hospital admission. The primary outcome was feasibility (recruitment, adherence and attrition rates) of the exercise program. The secondary outcomes were functional capacity, peripheral muscle strength, and health-related quality of life evaluated on admission and prior to hospital discharge. The adverse events rate was recorded during the intervention.
Twenty-six participants (58% female), aged 40 ± 15 (mean ± SD) years were included. The exercise program feasibility was demonstrated by 100% recruitment, 86% exercise adherence and 12% attrition rates with no adverse events recorded. Significant differences were observed in functional capacity ( = 0.03), upper and lower-limb muscle strength ( = 0.01) from admission to discharge (23 ± 7 d).
An individualized exercise training program based on daily clinical parameters is feasible for hospitalized patients undergoing hematopoietic stem cell transplantation. This intervention warrants further investigation in a randomized controlled trial. Implications for rehabilitation The individualized in-hospital exercise training program guided by daily clinical, hemodynamic and hematologic parameters is feasible, safe and with good adherence in people undergoing hematopoietic stem cell transplantation. People undergoing hematopoietic stem cell transplantation may improve functional capacity and upper and lower limb muscle strength following in-hospital exercise training program. The individualized in-hospital exercise training program could tentatively be introduced as part of the rehabilitation process in people undergoing hematopoietic stem cell transplantation.
本研究旨在评估针对接受造血干细胞移植患者的个体化运动方案的可行性。
这是一项针对接受造血干细胞移植患者的个体化住院运动训练方案的可行性研究。参与者根据每日临床、血液动力学和血液学评估来执行运动方案。该方案在住院期间每天进行 20-40 分钟。主要结局是运动方案的可行性（招募率、依从率和脱落率）。次要结局是在入院时和出院前评估的功能性能力、周围肌肉力量和健康相关生活质量。在干预期间记录不良事件发生率。
26 名参与者（58%为女性），年龄 40±15（平均值±标准差）岁。100%的招募率、86%的运动依从率和 12%的脱落率证明了运动方案的可行性，且无不良事件记录。从入院到出院，功能性能力（ = 0.03）、上下肢肌肉力量（ = 0.01）均有显著差异。
基于每日临床参数的个体化运动训练方案对接受造血干细胞移植的住院患者是可行的。该干预措施需要进一步在随机对照试验中进行研究。
由每日临床、血液动力学和血液学参数指导的个体化住院运动训练方案在接受造血干细胞移植的患者中是可行的、安全的，且依从性良好。接受造血干细胞移植的患者可能会在住院运动训练方案后改善功能性能力和上下肢肌肉力量。个体化住院运动训练方案可作为造血干细胞移植患者康复过程的一部分进行尝试。
