Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hôpital Kirchberg 9, rue Edward Steichen, L-2540 Luxembourg, Luxembourg.
College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, South Korea.
Biochem Pharmacol. 2019 Apr;162:55-70. doi: 10.1016/j.bcp.2018.12.016. Epub 2019 Jan 5.
Natural compounds act as immunoadjuvants as their therapeutic effects trigger cancer stress response and release of damage-associated molecular patterns (DAMPs). These reactions occur through an increase in the immunogenicity of cancer cells that undergo stress followed by immunogenic cell death (ICD). These processes result in a chemotherapeutic response with a potent immune-mediating reaction. Natural compounds that induce ICD may function as an interesting approach in converting cancer into its own vaccine. However, multiple parameters determine whether a compound can act as an ICD inducer, including the nature of the inducer, the premortem stress pathways, the cell death pathways, the intrinsic antigenicity of the cell, and the potency and availability of an immune cell response. Thus, the identification of hallmarks of ICD is important in determining the prognostic biomarkers for new therapeutic approaches and combination treatments.
天然化合物作为免疫佐剂发挥作用，因为它们的治疗效果引发了癌症应激反应并释放损伤相关分子模式 (DAMPs)。这些反应是通过增加经历应激的癌细胞的免疫原性，随后发生免疫原性细胞死亡 (ICD) 而发生的。这些过程导致具有强大免疫介导反应的化疗反应。诱导 ICD 的天然化合物可能成为将癌症转化为自身疫苗的一种有趣方法。然而，多个参数决定了一种化合物是否可以作为 ICD 诱导剂，包括诱导剂的性质、预先存在的应激途径、细胞死亡途径、细胞的内在抗原性以及免疫细胞反应的效力和可及性。因此，确定 ICD 的特征对于确定新治疗方法和联合治疗的预后生物标志物很重要。
