Department of Oncology, Dong Fang Hospital, Beijing University of Chinese Medicine, Beijing, China.
Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Immunol. 2024 Oct 9;15:1470071. doi: 10.3389/fimmu.2024.1470071. eCollection 2024.
This review underscores the role of natural products in inducing immunogenic cell death (ICD) as a key strategy in tumor immunotherapy. It reveals that natural products can activate ICD through multiple pathways-apoptosis, autophagy, pyroptosis, and necroptosis-leading to the release of danger-associated molecular patterns (DAMPs), dendritic cell activation, and improved antigen presentation, which together stimulate a potent anti-tumor immune response. The study also demonstrates the enhanced therapeutic potential of combining natural products with immune checkpoint inhibitors. With a focus on translating preclinical findings into clinical practice, this review consolidates recent discoveries and suggests future research paths, offering both theoretical insights and practical guidance for advancing cancer immunotherapy.
这篇综述强调了天然产物在诱导免疫原性细胞死亡（ICD）中的作用，这是肿瘤免疫治疗的一个关键策略。它揭示了天然产物可以通过多种途径——凋亡、自噬、细胞焦亡和坏死性凋亡——激活 ICD，导致危险相关分子模式（DAMPs）的释放、树突状细胞的激活和抗原呈递的改善，从而共同刺激强烈的抗肿瘤免疫反应。该研究还表明，将天然产物与免疫检查点抑制剂联合使用可以增强治疗潜力。本综述侧重于将临床前研究结果转化为临床实践，总结了最近的发现，并提出了未来的研究方向，为推进癌症免疫治疗提供了理论见解和实用指导。
