Bajic Petar, Wolfe Alan J, Gupta Gopal N
Department of Urology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL.
Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL.
Urology. 2019 Apr;126:10-15. doi: 10.1016/j.urology.2018.12.034. Epub 2019 Jan 4.
Recent investigation has proven that the bladder is not sterile. However, the implications of this finding in the pathophysiology and management of urothelial cell carcinoma have not been fully described. In this review, we summarize the literature relating to the urinary and gastrointestinal microbiomes in the context of urothelial cell carcinoma. The bladder microbiome may relate to urothelial cell carcinoma pathogenesis/progression, act as a noninvasive and modifiable urinary biomarker and have implications in treatment using immunotherapy agents such as intravesical bacillus Calmette-Guerin. Investigators should continue to optimize techniques to characterize this intriguing new area of human health.
最近的研究已证实膀胱并非无菌。然而，这一发现对尿路上皮细胞癌病理生理学及治疗的影响尚未得到充分描述。在本综述中，我们总结了尿路上皮细胞癌背景下与泌尿及胃肠道微生物群相关的文献。膀胱微生物群可能与尿路上皮细胞癌的发病机制/进展有关，可作为一种非侵入性且可改变的尿液生物标志物，并对使用卡介苗等免疫治疗药物进行治疗有影响。研究人员应继续优化技术，以表征这一引人入胜的人类健康新领域。
