Kobayashi S, Okada M
Institute of Biological Sciences, University of Tsukuba, Ibaraki, Japan.
Cell Differ Dev. 1988 Nov;25 Suppl:25-9. doi: 10.1016/0922-3371(88)90096-2.
This article reviews recent analytical studies of cytoplasmic factors involved in a mechanism underlying pole cell formation in Drosophila embryogenesis. Polar plasm, or germ plasm, includes sources of two independent functions in the germ-line segregation from the somatic line: pole cell formation and commitment of pole cells to germ cells. The UV-caused inability of pole cell formation in embryos was restored by poly(A)+ RNA, of which cDNA was cloned. The nucleotide sequence of the cDNA was highly homologous with mitochondrial large rRNA.
本文综述了近期关于果蝇胚胎发育中极细胞形成机制所涉及的细胞质因子的分析研究。极性细胞质，即生殖细胞质，在从体细胞系中分离生殖系的过程中包含两种独立功能的来源：极细胞形成以及极细胞向生殖细胞的定向分化。胚胎中紫外线导致的极细胞形成能力丧失可通过聚腺苷酸加尾RNA恢复，其互补DNA（cDNA）已被克隆。该cDNA的核苷酸序列与线粒体大核糖体RNA高度同源。
