Department of Psychology, School of Public Health, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, China.
Department of Child Psychiatry of Shenzhen Kangning Hospital, Shenzhen Mental Health Center, Shenzhen University, Mental Health School, Shenzhen 518020, China.
J Affect Disord. 2019 Mar 1;246:738-744. doi: 10.1016/j.jad.2018.12.034. Epub 2018 Dec 17.
The mechanisms underlying the relationship between life events and psychological distress are unclear. However, evidence of genetic involvement, including the neuropeptide S receptor gene (NPSR1), exists.
A total of 600 Chinese adults were enrolled in this cross-sectional study using random cluster sampling. Demographic information, measures of life events and psychiatric symptoms, and fasting blood samples were collected.
Significant correlations were observed among life-event scores, somatization, and psychological distress (i.e., anxiety and depressive symptoms). Regression revealed life-event scores and somatization predicted anxiety, depressive symptoms, and psychological distress, while controlling for sex, age, income, education, and marital status. Structural equation modeling indicated that somatization mediated the association between life-event scores and psychological distress. Moreover, the mediating effect was influenced by the NPSR1 gene, suggesting that the NPSR1 polymorphisms rs324981, rs6947841, and rs6972158 influenced the association between life-event scores and somatization (ps < 0.05). The NPSR1 polymorphisms rs12673132 significantly affected the relationship of somatization with psychological distress (p < 0.05).
In conclusion, somatization mediated the association between life-event scores and psychological distress. The current study is the first to demonstrate this relationship with a Chinese sample, whereby the NPSR1 gene affects the mediating effect of somatization on the association between life-event scores and psychological distress.
生活事件与心理困扰之间关系的机制尚不清楚。然而，已有证据表明存在遗传因素的参与，包括神经肽 S 受体基因（NPSR1）。
采用随机整群抽样的方法，共纳入 600 名中国成年人进行横断面研究。收集人口统计学信息、生活事件和精神症状测量以及空腹血样。
生活事件评分、躯体化与心理困扰（即焦虑和抑郁症状）之间存在显著相关性。回归分析显示，生活事件评分和躯体化预测了焦虑、抑郁症状和心理困扰，同时控制了性别、年龄、收入、教育程度和婚姻状况。结构方程模型表明，躯体化在生活事件评分与心理困扰之间起中介作用。此外，这种中介作用受到 NPSR1 基因的影响，表明 NPSR1 基因多态性 rs324981、rs6947841 和 rs6972158 影响了生活事件评分与躯体化之间的关联（p 值均<0.05）。NPSR1 基因多态性 rs12673132 显著影响了躯体化与心理困扰之间的关系（p 值均<0.05）。
总之，躯体化在生活事件评分与心理困扰之间起中介作用。本研究首次在中国人群中证实了这一关系，其中 NPSR1 基因影响了躯体化在生活事件评分与心理困扰之间关联的中介作用。
