蛋白质N-同型半胱氨酸化与结直肠癌
Protein N-Homocysteinylation and Colorectal Cancer.
作者信息
Jakubowski Hieronim
机构信息
Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers-New Jersey Medical School, International Center for Public Health, 225 Warren Street, Newark, NJ 07103-3535, USA; Department of Biochemistry and Biotechnology, Poznań University of Life Sciences, Dojazd 11, 60-632 Poznań, Poland.
出版信息
Trends Cancer. 2019 Jan;5(1):7-10. doi: 10.1016/j.trecan.2018.10.006. Epub 2018 Nov 13.
High-fat diet is associated with elevated plasma homocysteine (Hcy), and both are linked to cancer. Although Hcy is not a coded amino acid, proteins do carry Hcy modifications formed via a pathway involving methionyl-tRNA synthetase-catalyzed metabolic conversion of Hcy to Hcy-thiolactone. Hcy-thiolactone then chemically reacts with protein lysine residues, affording KHcy-protein. Recently, Wang et al.[1] (Cell Rep. 2018;25:398-412.e6) showed that this pathway promotes colorectal cancer by impairing DNA damage repair.
高脂饮食与血浆同型半胱氨酸（Hcy）升高有关，二者均与癌症相关。尽管Hcy不是编码氨基酸，但蛋白质确实带有通过涉及甲硫氨酰 - tRNA合成酶催化的Hcy向Hcy - 硫内酯代谢转化途径形成的Hcy修饰。然后，Hcy - 硫内酯与蛋白质赖氨酸残基发生化学反应，生成KHcy - 蛋白质。最近，Wang等人[1]（《细胞报告》，2018年；25:398 - 412.e6）表明，该途径通过损害DNA损伤修复来促进结直肠癌。
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