Safi Mohammad-Ayman A
Department of Medical Microbiology and Parasitology, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. E-mail.
Saudi Med J. 2019 Jan;40(1):9-18. doi: 10.15537/smj.2019.1.23892.
To perform a meta-analysis for celiac diseases (CD) among at-risk populations in Kingdom of Saudi Arabia (KSA), as well as a comparison with our previously reported meta-analysis in the normal population.
In March 2018, at King Abdulaziz University, Jeddah, KSA we commenced a retrospective comprehensive database and journal search for CD among at-risk populations in SA. Data from each of the relevant articles were analyzed using the Statistical Package for Social Science Version 20 (Armonk, NY: IBM Corp.). and the comprehensive meta-analysis program (CMA). The collected data were part of a retrospective literature review and analysis. Thus, a written ethical approval was not obtained before commencing the study. Results: Sixteen articles were found covering type-1 diabetes mellitus (DM), short stature (SS), and down syndrome (DS). Ages 1-50 years . The prevalence of seropositive-CD was 15.6% with high heterogeneity (I2=80.353), while prevalence of biopsy-proven CD was 10.6% with high heterogeneity (I2=73.359). Another article reported the CD prevalence in the at-risk population as 18.4% for the seroprevalence and 6.9% for the biopsy-proven CD. Anti-transglutaminase (anti-tTG) was used in 12 studies; in the remaining 4 studies (EMA in 2, ARA with AGA in one and no details given in one study). Conclusion: Both the prevalence of biopsy-proven CD (10.6%) and seroprevalence (15.6%) were higher than those we previously reported in the normal population (1.4% and 2.7%). The female-to-male ratio (1.9/1) of CD patients was the same in normal and at-risk populations in SA. Meta-analysis for prevalence of CD in DM, SS, and DS separately in SA is recommended.
对沙特阿拉伯王国（KSA）高危人群中的乳糜泻（CD）进行荟萃分析，并与我们之前报道的正常人群荟萃分析进行比较。
2018年3月，在沙特阿拉伯吉达的阿卜杜勒阿齐兹国王大学，我们开始对沙特高危人群中的CD进行回顾性综合数据库和期刊检索。使用社会科学统计软件包第20版（纽约州阿蒙克：IBM公司）和综合荟萃分析程序（CMA）对每篇相关文章的数据进行分析。收集的数据是回顾性文献综述和分析的一部分。因此，在研究开始前未获得书面伦理批准。结果：共发现16篇文章，涵盖1型糖尿病（DM）、身材矮小（SS）和唐氏综合征（DS）。年龄在1至50岁之间。血清学阳性CD的患病率为15.6%，异质性高（I2 = 80.353），而活检证实的CD患病率为10.6%，异质性高（I2 = 73.359）。另一篇文章报道高危人群中CD的血清学患病率为18.4%，活检证实的CD患病率为6.9%。12项研究使用了抗转谷氨酰胺酶（抗tTG）；其余4项研究（2项使用EMA，1项使用ARA加AGA，1项未给出详细信息）。结论：活检证实的CD患病率（10.6%）和血清学患病率（15.6%）均高于我们之前在正常人群中报道的患病率（1.4%和2.7%）。沙特正常人群和高危人群中CD患者的女性与男性比例（1.9/1）相同。建议对沙特DM、SS和DS中CD的患病率分别进行荟萃分析。
