From the Daroff-Dell'Osso Ocular Motility Laboratory, Louis Stokes Cleveland Department of Veterans Affairs Medical Center and CASE Medical School; and the Department of Neurology, Case Western Reserve University and University Hospitals Case Medical Center, 10701 East Boulevard, Cleveland, OH, 44106, USA.
Cerebellum. 2019 Jun;18(3):605-614. doi: 10.1007/s12311-018-1001-y.
To review our studies and "top-down" models of saccadic intrusions and infantile nystagmus syndrome with the aim of hypothesizing areas of cerebellar connections controlling parts of the ocular motor subsystems involved in both types of function and dysfunction. The methods of eye-movement recording and modeling are described in detail in the cited references. Saccadic intrusions, such as square-wave jerks and square-wave oscillations, can be simulated by a single malfunction, whereas staircase saccadic intrusions required two independent malfunctions. The major infantile nystagmus syndrome waveforms are traceable to a failure to calibrate the damping ratio of the smooth pursuit system. The use of a behavioral ocular motor system model demonstrated how putative cerebellar dysfunctions could accurately simulate both the oscillations and the ocular motor responses seen in patients with both saccadic and pursuit disorders.
回顾我们关于扫视性闯入和婴儿型眼球震颤综合征的研究和“自上而下”模型，旨在假设控制与这两种功能和功能障碍相关的眼动子系统的小脑连接区域。眼球运动记录和建模的方法在引用的参考文献中详细描述。扫视性闯入，如方波急跳和方波摆动，可以通过单个故障来模拟，而阶梯式扫视性闯入则需要两个独立的故障。主要的婴儿型眼球震颤综合征波形可归因于未能校准平滑追踪系统的阻尼比。行为性眼动系统模型的应用表明，假定的小脑功能障碍如何能够准确地模拟在扫视和追踪障碍患者中看到的眼球运动反应和眼动性闯入。
