Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Adv Exp Med Biol. 2018;1105:171-180. doi: 10.1007/978-981-13-2200-6_11.
Single types of methodologies are no longer sufficient to adequately describe complex biological structures. As a result, integrated approaches that combine complementary data are being developed. This chapter describes the integration of nuclear magnetic resonance and small-angle scattering approaches to characterize solution structures of multi-domain proteins.
单一类型的方法已不再足以充分描述复杂的生物结构。因此，正在开发结合互补数据的综合方法。本章描述了将核磁共振和小角散射方法相结合来表征多结构域蛋白质溶液结构的方法。
