Luccioni R, Frances Y, Gass R, Schwab C, Santoni J P, Perret L
Service de Médecine Interne, Urgences C.H.U. Nord, Marseille, France.
Eur Heart J. 1988 Oct;9(10):1131-6. doi: 10.1093/oxfordjournals.eurheartj.a062410.
Repeated blood pressure recordings by non-invasive devices are of better predictive value than single measurements in the evaluation of antihypertensive treatment. Such a method has been used to establish the dose-effect relationship of perindopril. After a two-week placebo run-in period, 40 patients with essential hypertension (age 56.6 +/- 1.5 years, 31 males, nine females) were treated with placebo or 2, 4 or 8 mg of perindopril once daily for one month following a randomized double-blind design. They were included if at least 75% of diastolic blood pressure recordings, made over an 8 h diurnal period using an automatic blood pressure recorder, were greater than 95 mmHg on placebo. Values (mean +/- SEM) before and after treatment were assessed using analysis of variance. These data showed a significantly greater reduction of blood pressure with 4 mg and 8 mg daily doses compared to placebo and the 2 mg daily dose. Such results were not obtained with blood pressure levels recorded by a mercury sphygmomanometer, confirming the value of an automatic blood pressure recorder as a tool in therapeutic trials.
在评估抗高血压治疗时，通过非侵入性设备重复测量血压比单次测量具有更好的预测价值。这种方法已被用于确定培哚普利的剂量 - 效应关系。在为期两周的安慰剂导入期后，40例原发性高血压患者（年龄56.6±1.5岁，男性31例，女性9例）按照随机双盲设计，接受安慰剂或每日一次2、4或8毫克培哚普利治疗，为期一个月。如果使用自动血压记录仪在8小时日间时段进行的舒张压记录中，至少75%在服用安慰剂时大于95 mmHg，则将这些患者纳入研究。治疗前后的值（均值±标准误）采用方差分析进行评估。这些数据显示，与安慰剂和每日2毫克剂量相比，每日4毫克和8毫克剂量的血压降低幅度显著更大。使用汞柱式血压计记录的血压水平未得出这样的结果，这证实了自动血压记录仪作为治疗试验工具的价值。
