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基于人群的神经保护健康长寿纵向研究模型的方法学方法及挑战。

Methodology approaches and challenges in population-based longitudinal study of a neuroprotective model for healthy longevity.

机构信息

Faculty of Health Sciences, Center for Healthy Aging and Wellness, National University of Malaysia, Kuala Lumpur, Malaysia.

Institute of Gerontology, University Putra Malaysia, Serdang, Malaysia.

出版信息

Geriatr Gerontol Int. 2019 Mar;19(3):233-239. doi: 10.1111/ggi.13598. Epub 2019 Jan 7.

DOI:10.1111/ggi.13598
PMID:30618211
Abstract

AIM

The 36-month Long-Term Research Grant Scheme project: Towards Usual Aging - Neuroprotective Model for Healthy Longevity among Malaysian Elderly was designed to address multidimensional aspects including psychosocial, biophysical health, nutrition and dietary pattern, and auditory and visual function to highlight the magnitude of these associations in a single study.

METHODS

A total of 2322 respondents aged ≥60 years were recruited at baseline using the multistage sampling method, followed up at 18 months and 36 months.

RESULTS

Response rates at baseline, 18 months and 36 months were 87.8%, 77.3% and 67.1%, respectively. At baseline, the prevalence of successful aging, usual aging and mild cognitive impairment was 11%, 73% and 16%, respectively. The prevalence of single and multimorbidity at baseline were 25.9% and 50.3%, respectively. The incidence rates of mild cognitive impairment at 18 months and 36 months were 6.5 and 5.6 per 100 person-years. The incidence rates of multimorbidity at 18 months and 36 months were 23.7 and 21.5 per 100 person-years, respectively.

CONCLUSIONS

The Long-Term Research Grant Scheme project: Towards Usual Aging study provides an opportunity to investigate the interactions between wide ranges of aspects of the older population in a nationally representative sample of the older population. Geriatr Gerontol Int 2019; 19: 233-239.

摘要

目的

36 个月长期研究资助计划项目:迈向马来西亚老年人的正常衰老-神经保护健康长寿模型旨在解决多维方面的问题,包括心理社会、生物物理健康、营养和饮食模式以及听觉和视觉功能,以在一项研究中突出这些关联的重要性。

方法

采用多阶段抽样法,在基线时共招募了 2322 名年龄≥60 岁的受访者,在 18 个月和 36 个月时进行随访。

结果

基线、18 个月和 36 个月的应答率分别为 87.8%、77.3%和 67.1%。基线时,成功老龄化、正常老龄化和轻度认知障碍的患病率分别为 11%、73%和 16%。基线时单病种和多病种的患病率分别为 25.9%和 50.3%。18 个月和 36 个月时轻度认知障碍的发病率分别为每 100 人年 6.5 和 5.6 例。18 个月和 36 个月时多病种的发病率分别为每 100 人年 23.7 和 21.5 例。

结论

长期研究资助计划项目:迈向正常衰老研究为在具有全国代表性的老年人群体样本中研究老年人群体各方面之间的相互作用提供了机会。老年医学与老年病学国际 2019;19:233-239。

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