Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
Departamento de Ciências Farmacêuticas, Universidade Regional de Blumenau, Blumenau, SC, Brazil.
Nat Prod Res. 2020 Sep;34(18):2683-2688. doi: 10.1080/14786419.2018.1550760. Epub 2019 Jan 8.
Alzheimer's disease and diabetes mellitus are contemporary diseases of great concern. Phenolic compounds are linked to several health benefits and could lead to novel strategies to combat these ailments. The objective of this study was to evaluate by electrophoretically-mediated microanalysis the potential inhibitory activity of the fruit juices from ("jaboticaba") and ("pitanga") toward acetylcholinesterase (AChE) and α-glucosidase, target enzymes in strategies for the treatment of these diseases. The phenolic profiles of the samples were also investigated. Jaboticaba and pitanga juices inhibited 85.90 ± 1.73 and 52.67 ± 1.24% of AChE activity at 5 mg mL, and 57.91 ± 2.60 and 69.47 ± 2.89% of α-glucosidase activity at 1 mg mL, respectively. Total phenolic content of the juices were 303.54 ± 28.28 and 367.00 ± 11.42 mgGA L, respectively. The observed inhibitory activity can be explained, at least in part, by the presence of the phenolic compounds.
阿尔茨海默病和糖尿病是当前备受关注的重大疾病。酚类化合物与多种健康益处有关，可能为治疗这些疾病提供新的策略。本研究旨在通过电泳介导的微分析评估“嘉宝果”和“巴西莓”果汁对乙酰胆碱酯酶（AChE）和α-葡萄糖苷酶的潜在抑制活性，这两种酶是治疗这些疾病的策略中的靶标酶。还研究了样品的酚类成分。嘉宝果和巴西莓汁在 5mg/mL 时分别抑制了 85.90±1.73%和 52.67±1.24%的 AChE 活性，在 1mg/mL 时分别抑制了 57.91±2.60%和 69.47±2.89%的α-葡萄糖苷酶活性。果汁中的总酚含量分别为 303.54±28.28 和 367.00±11.42mgGA/L。观察到的抑制活性至少部分可以用酚类化合物的存在来解释。
