Fundação Universidade Regional de Blumenau - FURB, Blumenau, Brazil.
Sociedade Educacional Santa Catarina - Unisociesc, Jaraguá do Sul, Brazil.
Nat Prod Res. 2022 Feb;36(4):1134-1137. doi: 10.1080/14786419.2020.1855640. Epub 2020 Dec 7.
DC. (Myrtaceae), popularly known as "cereja-do-Rio-Grande", is a native tree from Brazil, popularly used as a hypoglycemiant. Crude hydroalcoholic extract (CHE) and fractions (insoluble (FI), dichloromethane (FDM), ethyl acetate (FEA) and butanol (FBu)) of leaves were assessed to determine the phenolic chemical composition by HPLC-ESI-MS/MS. 10 compounds were identified, being 7 new for this species: rutin, isoquercitrin, luteolin-7--rutinoside, mandelic acid, naringenin, luteolin-7--glucoside and salicylic acid. Extract and fractions showed inhibitory activity on acetylcholinesterase (AchE) enzyme (best result: IC = 44.19 µg mL, for FEA) and α-glucosidase (α-Glu) (best result: IC = 31.25 ± 0.15 µg mL, for CHE). The observed antioxidant and inhibitory activity on the AchE and α-Glu is due to, at least in part, the presence of phenolic compounds in the samples.
DC.（桃金娘科），俗称“Rio-Grande 樱桃”，是一种原产于巴西的乔木，常被用作降血糖剂。对叶片的粗水醇提取物（CHE）和馏分（不溶性馏分（FI）、二氯甲烷（FDM）、乙酸乙酯（FEA）和正丁醇（FBu））进行评估，通过 HPLC-ESI-MS/MS 确定其酚类化学成分。鉴定出 10 种化合物，其中 7 种为该种的新化合物：芦丁、异槲皮苷、木樨草素-7-O-芦丁糖苷、扁桃酸、柚皮苷、木樨草素-7-O-葡萄糖苷和水杨酸。提取物和馏分对乙酰胆碱酯酶（AchE）酶（最佳结果：IC = 44.19 µg mL，FEA）和α-葡萄糖苷酶（α-Glu）（最佳结果：IC = 31.25 ± 0.15 µg mL，CHE）具有抑制活性。观察到的抗氧化和对 AchE 和 α-Glu 的抑制活性至少部分归因于样品中酚类化合物的存在。
