NUPICS, Faculdade de Farmácia, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
Laboratório de Autoimunidade e Imunofarmacologia, Departamento de Ciências da Saúde, Universidade Federal de Santa Catarina, Araranguá, Santa Catarina, Brazil.
Nat Prod Res. 2021 May;35(10):1727-1731. doi: 10.1080/14786419.2019.1633642. Epub 2019 Jun 26.
Jaboticaba, (Mart.) Kausel, is a Brazilian berry traditionally used in folk medicine as treatment for some health conditions. Phenolic compounds such as flavonoids and anthocyanins have previously been detected in the fruit. This current study aimed to evaluate the toxicological effects of jaboticaba peel extract (JPE) on , L929, and MDA-MB-231 cell lines. Besides, JPE antioxidant, acetylcholinesterase, and antifungal activities, and elemental analysis CHNS were also tested. JPE had moderate toxicity (LD = 360.92 μg mL) on , non-toxic effect on L929 cell line, and decreased the viability of cancer cell line MDA at 1,000 µg mL and 500 µg mL concentrations. The antioxidant activity toward 2,2-diphenyl-1-picrylhydrazyl (DPPH) performed IC = 37.45 ± 0.17 µg mL, whereas 45.7% of acetylcholinesterase activity was inhibited. By its elemental composition, JPE is an alternative food supplement and dermocosmetic component. Antifungal potential toward Candida strains was not observed.
嘉宝果，（Mart.）Kausel，是一种巴西浆果，传统上在民间医学中用于治疗一些健康状况。先前已经在果实中检测到了酚类化合物，如类黄酮和花青素。本研究旨在评估嘉宝果果皮提取物（JPE）对、L929 和 MDA-MB-231 细胞系的毒理学影响。此外，还测试了 JPE 的抗氧化、乙酰胆碱酯酶和抗真菌活性以及 CHNS 元素分析。JPE 对有毒，LD = 360.92 μg mL，对 L929 细胞系无毒性作用，在 1000 μg mL 和 500 μg mL 浓度下降低了 MDA 癌细胞系的活力。对 2,2-二苯基-1-苦基肼（DPPH）的抗氧化活性表现出 IC = 37.45 ± 0.17 μg mL，而乙酰胆碱酯酶活性抑制了 45.7%。根据其元素组成，JPE 是一种替代的食品补充剂和皮肤化妆品成分。对念珠菌菌株没有观察到抗真菌潜力。
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