Granoff D M, Sargent E, Jolivette D
Am J Dis Child. 1978 May;132(5):488-90. doi: 10.1001/archpedi.1978.02120300048009.
Three children had osteomyelitis due to Haemophilus influenzae type b. They were seen with signs and symptoms indistinguishable from infection caused by other organisms. One child was initially misdiagnosed as having septic arthritis because of failure to appreciate that Hemophilus may also cause bone infection. In the second patient osteomyelitis and arthritis developed during ampicillin sodium therapy for treatment of Hemophilus meningitis. His initial infection was caused by an ampicillin-sensitive isolate but his orthopedic infection subsequently responded to therapy only after changing to a regimen of chloramphenicol. In the third patient, bone scintigraphy was helpful in diagnosis since serial roentgenograms were not diagnostic of osteomyelitis. The anticapsular antibody responses of these patients were measured by radioimmune assay. The levels found were low but comparable to age-matched control children with H influenzae type b meningitis.
三名儿童患有由 b 型流感嗜血杆菌引起的骨髓炎。他们出现的体征和症状与其他病原体引起的感染难以区分。一名儿童最初被误诊为化脓性关节炎，原因是没有认识到嗜血杆菌也可能导致骨感染。在第二名患者中，在使用氨苄西林钠治疗 b 型流感嗜血杆菌脑膜炎期间发生了骨髓炎和关节炎。他最初的感染是由对氨苄西林敏感的菌株引起的，但他的骨科感染在改用氯霉素治疗方案后才对治疗产生反应。在第三名患者中，骨闪烁扫描有助于诊断，因为连续的 X 光片不能诊断骨髓炎。通过放射免疫测定法测量了这些患者的抗荚膜抗体反应。发现的水平较低，但与年龄匹配的 b 型流感嗜血杆菌脑膜炎对照儿童相当。
