阿普唑仑、劳拉西泮、地西泮、甲喹酮与安慰剂滥用倾向的对比研究。

Comparative study of the abuse liability of alprazolam, lorazepam, diazepam, methaqualone, and placebo.

作者信息

Orzack M H, Friedman L, Dessain E, Bird M, Beake B, McEachern J, Cole J O

机构信息

McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02178.

出版信息

Int J Addict. 1988 May;23(5):449-67. doi: 10.3109/10826088809039211.

DOI:10.3109/10826088809039211

PMID:3061941

Abstract

Subjective effects of two benzodiazepines--alprazolam and lorazepam--were compared with two drugs of known abuse potential--diazepam and methaqualone--and placebo. This double-blind, crossover trial tested 30 casual recreational sedative users in a seminaturalistic setting. Methaqualone was more euphoriant and less sedative than the benzodiazepines. Diazepam and lorazepam were more euphoriant than placebo; alprazolam's euphoriant effect did not differ from these treatments. On other measures of abuse liability the benzodiazepines rated similarly, diazepam rating highest.

摘要

将两种苯二氮䓬类药物——阿普唑仑和劳拉西泮——与两种已知具有滥用潜力的药物——地西泮和甲喹酮——以及安慰剂的主观效果进行了比较。这项双盲、交叉试验在半自然环境中对30名偶尔使用镇静剂的休闲使用者进行了测试。甲喹酮比苯二氮䓬类药物更具欣快感且镇静作用更弱。地西泮和劳拉西泮比安慰剂更具欣快感；阿普唑仑的欣快效果与这些治疗方法没有差异。在其他滥用可能性指标上，苯二氮䓬类药物的评分相似，地西泮评分最高。