以恶性组织细胞增多症告终的T细胞急性淋巴细胞白血病。
T cell acute lymphocytic leukemia terminating as malignant histiocytosis.
作者信息
Skoog D P, Feagler J R
出版信息
Am J Med. 1978 Apr;64(4):678-82. doi: 10.1016/0002-9343(78)90590-9.
Less than 200 cases of malignant histiocytosis (histiocytic medullary reticulosis) have been reported in the literature. Five previously reported cases and the case reported in this article have been preceded by acute lymphocytic leukemia. All of these cases have had similar courses characterized by prompt response of the leukemia to chemotherapy followed in three to six months by the onset of rapidly fatal malignant histiocytosis. The leukemic lymphoblasts in the two cases studied for lymphocyte surface markers had T cell markers. No residual leukemia was identified at autopsy in four of the six cases.
文献中报道的恶性组织细胞增多症（组织细胞性髓性网状细胞增多症）病例不足200例。先前报道的5例病例以及本文报道的病例之前均有急性淋巴细胞白血病。所有这些病例都有相似的病程，其特征为白血病对化疗迅速反应，三到六个月后迅速致命的恶性组织细胞增多症发作。对两例进行淋巴细胞表面标志物研究的病例中，白血病原始淋巴细胞具有T细胞标志物。6例病例中有4例在尸检时未发现残留白血病。
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