Potter M N, Foot A B, Oakhill A
Department of Paediatric Haematology and Oncology, Royal Hospital for Sick Children, Bristol.
J Clin Pathol. 1991 Apr;44(4):297-9. doi: 10.1136/jcp.44.4.297.
At the height of the United Kingdom influenza A epidemic in December 1989, three children receiving treatment for non-T cell acute leukaemia developed pancytopenia with concomitant influenza A infection. Bone marrow histology showed prominent marrow erythrophagocytosis by morphologically mature histiocytes, consistent with the picture of virus associated haemophagocytic syndrome (VAHS). In two cases there was an initial spontaneous recovery, though recurrence of VAHS developed in one case in association with a different viral infection (cytomegalovirus) following autologous bone marrow transplantation. The third child died from cardiorespiratory failure secondary to infection with influenza A and Klebsiella pneumoniae sepsis. It is suggested that influenza A should be added to the list of infective causative agents.
在1989年12月英国甲型流感疫情高峰期，三名接受非T细胞急性白血病治疗的儿童在感染甲型流感的同时出现了全血细胞减少症。骨髓组织学检查显示，形态成熟的组织细胞显著吞噬骨髓红细胞，符合病毒相关性噬血细胞综合征（VAHS）的表现。两例患者最初自发恢复，不过其中一例在自体骨髓移植后因另一种病毒感染（巨细胞病毒）而复发了VAHS。第三名儿童死于甲型流感感染及肺炎克雷伯菌败血症继发的心肺功能衰竭。建议将甲型流感列入感染性致病因子名单。
